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 HBV mutation literature information.


  Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes.
 PMID: 22510826       2012       Memorias do Instituto Oswaldo Cruz
Abstract: Six out of nine isolates that contained the rtM204I mutation belonged to genotype D and half of them displayed a single mutation.


  Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing.
 PMID: 22523569       2012       PloS one
Abstract: Moreover, various abundances of clones resistant to NA were common in both the liver and serum of treatment-naïve patients, and the proportion of M204VI mutants resistant to lamivudine and entecavir expanded in response to entecavir treatment in the serum of 35.7% (5/14) of patients, suggesting the putative risk of developing drug resistance to NA.


  HIV and Hepatitis B coinfection among perinatally HIV-infected Thai adolescents.
 PMID: 22592516       2012       The Pediatric infectious disease journal
Abstract: Among adolescents with chronic HBV infection, 88% have received lamivudine; however, 69% have HBV DNA >10 copies/mL and 75% had the rtM204V/I mutation.
Abstract: HBV DNA quantitation and rtM204V/I mutation analysis (lamivudine resistance-associated mutatio
Method: HBV Mutation Analysis assessed the presence of rtM204V/I by pinpointing the change in the YMDD motif; HBV nucleotides were translated into amino acid sequences using the translation tool provided by the ExPASy Proteomics Server (available at: http://www.expasy.ch/tools/dna.html) at the Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University.


  Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome.
 PMID: 22666402       2012       PloS one
Table: M204I
Discussion: In the longitudinal study of the patient sequentially treated with LMV, ADV, and ETV monotherapies, the blind SD-based algorithm ranked the 7 NA resistance-related aa substitutions previously detected by routine analysis (rtL180M, rtM204V, rtS202G, rtV207I, rtA181T, rtV173L and rtI169T) as the most variable, and 5 additional NA resistance substitutions (rtV191I,


  Detection of mixed populations of wild-type and YMDD hepatitis B variants by pyrosequencing in acutely and chronically infected patients.
 PMID: 22672436       2012       BMC microbiology
Abstract: The primary LAM resistance mutation (rtM204V/I) occurs in the YMDD motif of HBV polymerase.
Introduction: The main site within the HBV rt protein that is associated with LAM resistance is residue 204 in the highly conserved tyrosine-methionine
Result: Interestingly, all but two individuals whose major virus population was composed of WT isolates and a small percentage of resistant variants detected by pyrosequencing had a YIDD variant as a minor subpopulation, suggesting that the rtM204I mutation may naturally occur more often and replicate more efficiently than YVDD variants in environments with little or no selection pressures.


  Lamivudine plus adefovir or telbivudine plus adefovir for chronic hepatitis B patients with suboptimal response to adefovir.
 PMID: 22728692       2012       Antiviral therapy
Abstract: After 12-month treatment, 8.1% (3/37) of patients in group A and 5.7% (2/35) of patients in group B had VR; among patients in group A, two had rtM204V/I and rtL180M and one had rtN236T, whereas the two patients in group B had rtM204I+rtL180M.


  "Evaluation of a ""home-made"" method to determine viral genotype and characterize mutations conferring drug resistance in chronic hepatitis B patients."
 PMID: 22767306       2012       Le infezioni in medicina
Abstract: M204I mutations were more frequent in genotype D, M204V in genotype A isolates.
Abstract: The resistance loci were also reliably detected with mostly combined L180M and M204V/I mutations as the local patterns.


  Long-term hepatitis B virus (HBV) response to lamivudine-containing highly active antiretroviral therapy in HIV-HBV co-infected patients in Thailand.
 PMID: 22860080       2012       PloS one
Abstract: HBV breakthrough was observed only in HBeAg-positive patients and 6 of 7 patients presenting HBV breakthrough had the rtM204I/V mutations associated with 3TC resistance along with rtL180M and/or rtV173L.
Result: Late HBV breakthrough occurred in 3 patients and was associated with the emergence of 3TC-resistance mutations: rtV173L+L180M+M204I, rtL180M+M204V and rtL180M+M204I.


  Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.
 PMID: 22882650       2012       Liver international
Abstract: RESULTS: Among 467 consecutive eligible patients (262 chronic hepatitis B patients, 105 cirrhotic patients and 100 hepatocellular carcinoma patients), the nucleos(t)ide analogues-related mutations (rtI169T, rtV173L, rtL180M, rtA181T, rtS202C, rtM204I/V, rtN236T) were found.
Result: Among patients with lamivudine related resistan


  Emergence of lamivudine resistance hepatitis B virus mutations in pregnant women infected with HBV and HIV receiving antiretroviral prophylaxis for the prevention of mother-to-infant transmission in Malawi.
 PMID: 22930502       2012       Journal of medical virology
Abstract: Resistance mutations (M204I in five cases and L180M + M204I/V in one case) were present in 6 (28.6%) patients.



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