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 HBV mutation literature information.


  Hepatitis B Virus preS/S Truncation Mutant rtM204I/sW196* Increases Carcinogenesis through Deregulated HIF1A, MGST2, and TGFbi.
 PMID: 27313669       2016       Experimental and therapeutic medicine
Abstract: At the initiation of sequential monotherapy with ADV, LAM-resistant variants (rtM204V/I and rtL180M) were detected in the three patients.
Abstract: During 30-41 months of ADV-ETV combination therapy, viral load reduction was 2.59-3.28 log10 copies/ml; ADV-resistant variants rtA181T/V and rtN236T were undetectable following 11-24 months of combination therapy; and rtL180M and rtM204I/V remained dominant in the viral population.
Abstract: In conclusion, the results of the present study suggested that, in patients with LAM and ADV-resista


  Hepatitis B infection in HIV-1-infected patients receiving highly active antiretroviral therapy in Lome, Togo: Prevalence and molecular consequences.
 PMID: 27245734       2016       South African medical journal
Abstract: The detected resistance mutations were rtL180M (14/15 patients) and rtM204V/I (15/15).


  Betaine Inhibits Hepatitis B Virus with an Advantage of Decreasing Resistance to Lamivudine and Interferon alpha.
 PMID: 27144395       2016       Journal of agricultural and food chemistry
Abstract: BET suppressed HBV DNA rebound produced by the resistance of HBV to lamivudine and decreased the resistance mutation (rtM204V/I) of HBV DNA.


  De novo entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations resulting from sequential therapy with adefovir dipivoxil, and lamivudine.
 PMID: 27079793       2016       Annals of clinical microbiology and antimicrobials
Abstract: Specifically, we found one rtM204I+rtL180 M+rtM250 V+rtA181 V clone among 23 clones from patient 1 (4.35 %), one rtM204 V+vrtL180 M +rtM250 V+rtA181 V clone among 24 clones from patient 2 (4.17 %), and 2 clones harboring rtM204 V+rtL180 M+rtM250 V+rt


  Overt and occult hepatitis B virus infection among treatment-naive HIV-infected patients in Brazil.
 PMID: 27061406       2016       Journal of medical virology
Abstract: One patient had the M204I and L180M drug-resistance mutations (polymerase).


  Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2.
 PMID: 27006281       2016       Infection, genetics and evolution
Abstract: In addition, two patients harboring drug resistance mutations rtL80V+rtM204I and rtL180M+rtM204V were found.


  [Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology].
 PMID: 26983387       2016       Zhonghua gan zang bing za zhi
Abstract: Each of the NAs had dominant drug-resistant mutational profiles, with rtM204I+rtL180M+-rtL80I (30.9%) for LAM, rtA181T/N (21.3%), rtS213T/N (21.3%) and rtV214A (21.3%) for ADV, rtl180M (48%) for ETV, rtM204I for LdT, and rtA194T for tenofovir disoproxil fumarate (TDF).


  Evolution of entecavir-resistant hepatitis B virus during entecavir and adefovir dipivoxil combination therapy.
 PMID: 26889227       2016       Experimental and therapeutic medicine
Abstract: In patient B, the rtL180M, rtM204I and rtM204V mutants were present in ~70, 30 and 10% of the viral populations, respectively, at the time of study entry.
Result: 2B may be summarized as follows: i) At baseline,
Discussion: However, the LAM-resistant variant, rtM204I, was detected after an 18-month period of ETV therapy, which is consistent with previous studies that observed that ETV-resistant variants preceded by LAM-resistant variants.


  Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China.
 PMID: 26876337       2016       The Brazilian journal of infectious diseases
Abstract: Mutations in HBV DNA polymerase were detected in 24 patients (8.9%) including rtM204I/V (n=6), rtN236T (n=5), rtM250V (n=2), rtL180M (n=2), rtT184G (n=1), rtM207I (n=1), rtS202I (n=1), rtM204V/I & rtL180M (n=5), and rtM204I &


  Antiviral efficacy of entecavir versus entecavir plus adefovir for hepatitis B virus rtA181V/T mutants alone.
 PMID: 26831605       2016       Saudi journal of gastroenterology
Discussion: Newly developed HBV rtM204I and rtP237H mutants were detected, and the pre-existing HBV rtA181V mutant disappeared completely through rescue therapy.



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