Discussion: In South Africa, rtM204I has been detected in therapy-naive HBV/HIV co-infected individuals and rtM204V in treated HBV mono-infected participants.
Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation.
Introduction: However, in the presence of rtM204I/V mutations, ETV resistance arose with the coexistence of rtI169T, rtL180M, rtT184A/F/G/I/L/S, rtS202G/I, or rtM250V mutations.
Introduction: The major TBV resistant mutant is rtM204I.
Introduction: The most frequently encountered LAM-resistant mutation at the catalytic YMDD motif is rtM204V/I
Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment.
PMID: 23197889
2012
World journal of gastroenterology
Abstract: The emergence of resistance mutations to LMV, such as rtM204V/I and/or rtL180M, were found in all patients.
Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B.
PMID: 23322992
2012
World journal of gastroenterology
Abstract: The virologic breakthrough in the clevudine group occurred in 9 (7.6%) patients at weeks 48 and 15 (12.7%) patients at week 96, which primarily corresponded to genotypic mutations of rtM204I and/or rtL180M.
Efficacy of 3 years of adefovir monotherapy in chronic hepatitis B patients with lamivudine resistance.
Abstract: The remaining 49 cases underwent biochemical rebound accompanied by rtM204I/V or rtL180M mutation.
[Mutation analysis of the HBV reverse transcriptase in nucleos(t)ide-treated patients with chronic HBV infection].
PMID: 23627028
2012
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: RtM204 mutations were detected at the highest frequency among 63 mutants (40/63, 63.49%) and found to display 11 combination mutation patterns, in which rtM204I were associated with rtL80I/V and rtL180M, and rtM204V were associated with rtL1l80M, respectively.
Impact of hepatitis B e antigen-suppressing mutations on the replication efficiency of entecavir-resistant hepatitis B virus strains.
Abstract: To comprehensively analyse the impact of PC or BCP mutations on viral replication of ETV-resistant HBV mutants, replication-competent HBV constructs were generated harbouring lamivudine resistance (rtM204V/rtL180M, rtM204I) plus ETV resistance (rtS202G, rtS202I or rtT184G) on wild-type (WT)-, PC- and BCP-backgrounds.
Characterization of hepatitis virus B isolated from a multi-drug refractory patient.
Abstract: Lamivudine (LAM)-resistant mutations, rtL180M and rtM204V/I were detected in 86.4% of clones.
Variable influence of mutational patterns in reverse-transcriptase domain on replication capacity of hepatitis B virus isolates from antiviral-experienced patients.
PMID: 21056552
2011
Clinica chimica acta; international journal of clinical chemistry
Abstract: Compared to wild-type counterpart, mutant rtL217P produced 1.98-fold higher replicative intermediate level, and mutant rtM204I+rtL217P increased the replicative intermediate level to 1.20 fold.
Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection.
Abstract: Double mutations rtM204I and rtL180M were detected more frequently in genotype C than in genotype B virus, and patients infected with this mutant had higher alanine transaminase levels than those infected with mutant containing the rtM204I substitution alone.
Result: By contrast, rtM204I was more often accompanied by rtL80I (36.5%) than rtM204V (3.9%).
Result: Of the resistance mutations detected in patients who received monotherapies, rtM204I (32.2%), rt
HBV mutation literature information.
PMID: 
2012
PloS one
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