literature

HBV mutation literature information.

Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure.

PMID: 18331765 2008 Journal of hepatology

Abstract: RESULTS: Clonal analysis revealed the co-localization on the same HBV genome of rtA181T/V with rtN236T, but not with rtM204V/I mutations following lamivudine, adefovir or lamivudine+adefovir breakthrough.

[Mutations of HBV polymerase gene sequence in lamivudine-resistant chronic hepatitis B patients].

PMID: 18504191 2008 Nan fang yi ke da xue xue bao

Abstract: RESULTS: Lamivudine resistant mutation was detected in 103 patients, and the major mutations included rtL180M+rtM204V and rtM204I, accounting for 58.3% and 22.3%, respectively.

[A five-year analysis of HBV mutations in a multidrug-resistant patient with chronic hepatitis B].

PMID: 18647526 2008 Zhonghua gan zang bing za zhi

Abstract: RESULTS: Several mutations were identified in succession, including LAM-resistant mutations M204I/V and L180M+M204V, ETV-resistant mutation S202G, and HBeAg nonsense mutation G1896A.

Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus.

PMID: 18713056 2008 The Journal of infectious diseases

Abstract: BACKGROUND: Hepatitis B virus (HBV) establishes lamivudine resistance via the resistance-causative rtM204V/I mutation and the replication-compensatory rtL180M mutation.

Understanding the molecular basis of HBV drug resistance by molecular modeling.

PMID: 18765256 2008 Antiviral research

Abstract: In this regard, homology modeled structure of HBV-polymerase was used for minimization, conformational search and induced fit docking followed by binding energy calculation on wild-type as well as on mutant HBV-polymerases (L180M, M204V, M204I, L180M+M204V, L180M-M204I).

Result: A further binding mode study reveals a steric clash in case of M204I HBV due to the unfavorable position and orientation of a methyl group (Figure 13b) of I204 residue.

Result: Energetic results in Table 4 clearly indicates a significant low binding affinity of 3TC-TP (DeltaE = -346.7 KJ/mol) in comparison to dCTP (DeltaE = -426.5 KJ/mol) in

[Multiple-site analysis of HBV drug-resistant mutations in 340 patients with chronic hepatitis B].

PMID: 18983768 2008 Zhonghua gan zang bing za zhi

Abstract: M204V and M204I were the most common LAM-resistant mutations.

Abstract: LdT-resistance was observed as M204I.

[Development of clevudine resistance after switching from lamivudine in a patient with chronic hepatitis B].

PMID: 19077481 2008 The Korean journal of gastroenterology

Abstract: After the 6 months of clevudine therapy, the patient developed virologic breakthrough (>1.0chi10(8) copies/mL) as well as biochemical breakthrough, which was associated with the presence of rtM204I plus rtL80I mutant.

Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure.

PMID: 19669299 2008 Hepatology international

Abstract: Several major HBV-evolutionary NA-resistance pathways (rtM204I/V, rtN236T and rtA181T/V) have now been characterised.

Abstract: The rtM204V/I pathway is responsible for resistance to the L: -nucleosides, such as lamivudine (LMV), telbivudine (LdT) and clevudine (CLD), and also entecavir (ETV), whilst the rtN236T pathway is responsible for adefovir (ADV) and tenofovir (TFV) resistance.

In vitro study of the effects of precore and lamivudine-resistant mutations on hepatitis B virus replication.

PMID: 17215289 2007 Journal of virology

Abstract: Although the rtM204I mutation reduced the production of HBV replicative intermediates, no effect on the level of covalently closed circular DNA or HBV transcripts was observed at late time points.

Abstract: Coinfection studies with different ratios of wt and rtM204I baculoviruses showed that the rtM204I variant did not produce a product that inhibited HBV replication.

Abstract: However, the combination of the wt and rtM204I baculoviruses yielded HBV DNA levels at late time points that were greater than those for the wt alone, suggesting that wt polymerase may function in trans to boost rtM204I

"Molecular analysis of hepatitis B virus ""a"" determinant in asymptomatic and symptomatic Mexican carriers."

PMID: 17217533 2007 Virology journal

Discussion: The main mutations associated with LMV resistance are located at the RT gene in the 204 position (rtM204I/V), which is in the catalytic YMDD motif.

Discussion: Thus for mutations associated with LMV resistance, the rtM204V change is associated with a I195M change in the S gene (sI195M), while the rtM204I change is associated with three possible changes in the S gene, sW196S, sW196L,

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