Discussion: A recent meta-analysis has shown that the incidence of spontaneous primary and secondary mutations among untreated chronic hepatitis B patients was 4.9% for primary mutations of rtM204V/I, while the natural incidence of secondary rtL180M mutations was 2.7%.
Discussion: For example, dual rtL180M and M204V/I mutants were frequently found in patients in Italy, with three patients having triple mutation of rtV173L, rtL180M and M204V.
Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice.
Abstract: BACKGROUND AND AIMS: Entecavir (ETV) resistance of hepatitis B virus (HBV) conventionally requires rt184, 202, or 250 mutations plus lamivudine-resistance mutation (rtM204V/I +- L180M).
Introduction: Signature or cla
Result: The patterns of LAMr, in the composition of ETV-resistance mutations, included rtM204V+L180M (82.91%), rtM204I +-L180M (15.25%), and rtM204V /I+L180M (1.84%) (Table 1).
Table: M204I
Table: M204V/I
Prevalence of the entecavir-resistance-inducing mutation rtA186T in a large cohort of Chinese hepatitis B virus patients.
Abstract: Classical ETV-resistance mutations rtT184/S202/M250substitution+rtM204V/I+-L180M (LAM-r), rtA186T, and rtI163V were detected in 1252 (5.69%), 14 (0.06%), and 230 (1.05%) of the 22,009 patients, respectively.
Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.
Abstract: RESULTS: Five mutations (rtS106C [C], rtH126Y [Y], rtD134E [E], rtM204I/V, and rtL269I [I]) were commonly found in viral isolates from 2 patients.
High Prevalence of HBV Lamivudine-Resistant Mutations in HBV/HIV Co-Infected Patients on Antiretroviral Therapy in the Area with the Highest Prevalence of HIV/HBV Co-Infection in China.
Abstract: Previous studies revealed that ETV-resistant (ETVr) HBV DNA resulted from substitutions in the HBV reverse transcriptase (RT) at positions rtT184, rtS202, or rtM250 in combination with lamivudine resistance (LVDr) substitutions rtM204I/V+-rtL180M.
Discussion: Previous analyses have shown that the primary HBV substitutions at rtT184, rtS202, or rtM250 confer resistance to ETV when associated with LVDr substitutions rtM204V/I+-rt
HBV epidemiology and genetic diversity in an area of high prevalence of hepatitis B in southern Brazil.
PMID: 30092176
2018
The Brazilian journal of infectious diseases
Abstract: LAM-resistant mutation (rtM204I) and ADV-resistant mutations (rtA181V) were detected in only one patient each.
A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.
Discussion: A European study demonstrated that the most frequent primary mutation was rtM204V/I, found in 49% of treatment experienced patients, while in China rtM204I, rtN236T and rtL180M+rtM204V+rtV173L/rtS202G were also the most prevalent RAMs.
Discussion: A review of worldwide incidence of RAMs among treatment naive patients also described rtM204V/I as the most frequent, but with a much lower prevalence of 5%.
Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.
Abstract: Strong correlation was observed between sP120T and rtM204I/V (P < 0.001), and their co-presence determined an increased HBV-DNA.
Abstract: The immune-associated escape mutations and the NA-induced immune-escape mut
Method: We also analyzed the prevalence of the NA-induced immune-escape mutations sI195M, sI196S, and sE164D (resulting from drug-resistance mutation rtM204 V, rtM204I, and rtV173L) and stop-codons.
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Abstract: Eight mutations in RT (rtL80I, rtD134N, rtN139K/T/H, rtY141F, rtM204I/V, rtF221Y, rtI224V, and rtM309K) are significantly associated with HCC progression.
Method: A systematic review by Zhang et al revealed that the global incidence of rt
ViMRT
HBV mutation literature information.
PMID: 
2019
PeerJ
