Abstract: The point mutation of rtM204I and rtL180M appeared only in genotype B group.
Abstract: The rate of rtL180M/M204V mutation in genotype C group was significantly higher than that in genotype B group (77.8% to 25.0%), the same was true for the rtL180M/ M204I mutation (22.2% to 12.5%).
Abstract: There are four types of mutation: rtL180M/M204V, rtL180M/M204I, rt
Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir.
Abstract: Combination treatment including potent antiviral agents should be recommended for patients with pre-existing rtM204V/I mutations.
Abstract: RESULTS: During 3TC and ADV therapy, 11 patients had rtM204V/I mutations, 2 had rtA181V/T or rtN236T, 7 had both and 2 had no 3TC- or ADV
Abstract: Relative abundances of rtM204V/I mutations in total viral populations gradually increased under ETV rescue, whereas those with rtA181V/T and rtN236T mutations decreased.
Polymorphism rtQ215H in primary resistance to adefovir dipivoxil in hepatitis B virus infection: a case report.
Abstract: However, load changes for rtM204I alone were greater than those for the rtM204I + rtM204V mixed-type (P = 0.042, at both 40 and 52 weeks).
Abstract: Load changes in rtM204I and rtM204V with G1896A tended to be greater than those without.
Abstract: RESULTS: Changes in viral loads of rtM204I and rtM204V were similar.
Abstract: Viral changes in YMDD mutants (rt PMID: 17962902
2008
Infection
Abstract: We report an unusual case of a male adult patient who showed a prolonged persistence of the M204I mutation up to 24 months after lamivudine withdrawal followed by the emergence of new distinct YMDD mutants (namely M204V, V207L).
Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case.
PMID: 18171343
2008
Journal of gastroenterology and hepatology
Abstract: BACKGROUND AND AIM: Resistance to lamivudine therapy of chronic hepatitis B virus (HBV) infection occurs by mutation in the YMDD motif of the reverse transcriptase (rt) domain (rtM204V/I) of the virus polymerase, and is usually accompanied by rtL180M mutation.
Abstract: RESULTS: A peak of alanine aminotransferase and aspartate aminotransferase levels occurred after 19 months of lamivudine treatment, associated with the rtM204I mutation.
Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil.
Discussion: Single mutants in the YMDD motif (rtM204V/I) replicate substantially more slowly in vitro than the wild type.
Discussion: The resistance occurs by replacement of a methionine residue at position rt204 by either valine (rtM204V) or isoleucine (rtM204I), accompanied or not by a substitution at position rt180 and more rarely by a substitution at position rt173.
Discussion: The triple mutation rtV173L/rtL180M/ PMID: 18329126
2008
Journal of hepatology
Abstract: The M204V/I mutation was detected in 43% (15/35) and 15% (6/41) of each group, respectively.
HBV mutation literature information.
PMID: 
2009
Alimentary pharmacology & therapeutics
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