literature

HBV mutation literature information.

Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot.

PMID: 31880889 2019 Polish journal of microbiology

Table: M204I

Discussion: These were rtM204I/sW196L mutations (Table II).

Discussion: When analyzed in greater details, rtM204I, rtI233V, rtL80I, and rtL180M mutations were not detected before, and these mutations, particularly rtL80I and rtL180M, restore the activity of viral polymerase to near wild type levels, which helps to promote the replication of mutants.

Mutations in reverse transcriptase region of HBV affect Hepatitis B surface antigen titers and its correlation with HBV DNA.

PMID: 32087080 2019 Journal of infection in developing countries

Abstract: HBsAg was positively correlated with HBV DNA levels in the wild-type group (r = 0.322, p < 0.01), as well as in the M204I/V, L180M+M204I/V, A181T/V, and N236T subgroups, while no correlation was found in the A181T/V+N236T subgroup (r = 0.159, p = 0.217).

Abstract: RESULTS: HBsAg was lower in the wild-type and A181T/V+N236T groups as compared to the M204I/V, L180M+M204I/V and N236T groups.

Abstract: Then, the

Prevalence of the entecavir-resistance-inducing mutation rtA186T in a large cohort of Chinese hepatitis B virus patients.

PMID: 30796932 2019 Antiviral research

Abstract: Classical ETV-resistance mutations rtT184/S202/M250substitution+rtM204V/I+-L180M (LAM-r), rtA186T, and rtI163V were detected in 1252 (5.69%), 14 (0.06%), and 230 (1.05%) of the 22,009 patients, respectively.

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

PMID: 30794889 2019 Journal of hepatology

Abstract: RESULTS: Five mutations (rtS106C [C], rtH126Y [Y], rtD134E [E], rtM204I/V, and rtL269I [I]) were commonly found in viral isolates from 2 patients.

High Prevalence of HBV Lamivudine-Resistant Mutations in HBV/HIV Co-Infected Patients on Antiretroviral Therapy in the Area with the Highest Prevalence of HIV/HBV Co-Infection in China.

PMID: 30368502 2018 Intervirology

Abstract: The major pattern of lamivudine (3TC)-resistant mutations is L180M+M204I+L80I (35.7%).

Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis.

PMID: 30202825 2018 Hepatology communications

Abstract: Previous studies revealed that ETV-resistant (ETVr) HBV DNA resulted from substitutions in the HBV reverse transcriptase (RT) at positions rtT184, rtS202, or rtM250 in combination with lamivudine resistance (LVDr) substitutions rtM204I/V+-rtL180M.

Result: HBV substitutions at rtT184, rtS202, or rtM250 confer resistance to ETV when associated with LVDr substitutions rtM204V/I+-rt

Table: M204I

HBV epidemiology and genetic diversity in an area of high prevalence of hepatitis B in southern Brazil.

PMID: 30092176 2018 The Brazilian journal of infectious diseases

Abstract: LAM-resistant mutation (rtM204I) and ADV-resistant mutations (rtA181V) were detected in only one patient each.

A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.

PMID: 30080852 2018 PLoS neglected tropical diseases

Discussion: A European study demonstrated that the most frequent primary mutation was rtM204V/I, found in 49% of treatment experienced patients, while in China rtM204I, rtN236T and rtL180M+rtM204V+rtV173L/rtS202G were also the most prevalent RAMs.

Discussion: A review of worldwide incidence of RAMs among treatment naive patients also described rtM204V/I as the most frequent, but with a much lower prevalence of 5%.

Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.

PMID: 29859062 2018 BMC infectious diseases

Method: We also analyzed the prevalence of the NA-induced immune-escape mutations sI195M, sI196S, and sE164D (resulting from drug-resistance mutation rtM204 V, rtM204I, and rtV173L) and stop-codons.

Figure:

Figure: The NA-induced immune-escape mutations I195M, I196S, and E164D result from drug-resistance mutation M204 V, M204I, and V173 L (Torresi, 2002)

Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.

PMID: 29713126 2018 World journal of gastroenterology

Abstract: Eight mutations in RT (rtL80I, rtD134N, rtN139K/T/H, rtY141F, rtM204I/V, rtF221Y, rtI224V, and rtM309K) are significantly associated with HCC progression.

Conclusion: Eight mutations in RT region, rtL80I, <

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