Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.
Abstract: All occult HBV infection-associated Y100C and common diagnostic and vaccine-escape-associated P120T, G145R, K122R, M133L, M133T, Q129H, G130N, and T126S mutations were reliably detected by the assay, which consistently detected the presence of HBsAg in all 179 samples including samples with 11 novel mutations.
Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).
Molecular epidemiology of co-infection with hepatitis B virus and human immunodeficiency virus (HIV) among adult patients in Harare, Zimbabwe.
4Method: The S gene sequence was analyzed for mutations in the ""a"" determinant region (T116 N, P120S/T, I/T126S/A, Q129H/R, M133 L/T, K141E, P142S, D144E, and G145R), and other virulence associated mutations (N3S, V184A, and S204R)."
5Result: Among the isolates, 8.1% (11/135) had a mutation in the ""a"" determinant region including 2.2% (3/135) P120S/T, 2.2% (3/135) I/T126S/A, 3% (4/135) PMID: 28751727
2017
Scientific reports
Result: Notably, two T131N/M133T (a novel N-linked glycosylation site) double mutations associated with I126S were observed in our study.
Table: M133T
Discussion: T131N/M133T can create a novel N-linked glycosylation site, and play a role in some
Discussion: Additionally, a small amount of P127T, A128V, G130E, T131P/N, M133T/I, F134L and D144N mutations was observed in our study, including the less frequent T131N/M133T double mutations.
Prevalence of S gene mutations within the major hydrophilic region of hepatitis B virus in patients in Dongguan, southern China.
Abstract: Furthermore, the mutations sY100C, sQ101R/K, sS114A, sP120T, sT/I126A/N/S, sQ129R, sM133L/T/S and sG145R/A were prevalent in at least one genotype, with a frequency higher than 1%, which indicated that these mutations were relatively common.
Hepatitis B genotypes and surface antigen mutants present in Pakistani blood donors.
Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Discussion: Avellon reported M133T (2.2%), Q129H, M133I, F/Y134N (1.8%), F/Y134L, G145A (1.5%), and P120T (1.1%) as the most frequent mutations of S region, while G145R was found at a frequency of less than 1% (0.4%), while among them just Q129H was found in the current study.
HBV mutation literature information.
PMID: 
2018
Journal of clinical virology
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