Result: In addition, I/T126S (n = 4), I/T126V (n = 1), Q129L (n = 1), T131P (n = 2), M133T + T140I (n = 1), and S136Y (n = 1) mutants were detected as a predominant strain in 10 (9.3%) of the 107 HBV carriers who had not received the HB vaccine or HBIG.
Discussion: Direct sequencing showed that I/T126S, I/T126V, Q129L, T131P, M133T + T140I, and S136Y mutants were present as a predominant strain in 107 HBV carriers.
A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
Abstract: RESULTS: Three HBV variants (T123A, M133L and T143M) and a wild type sequence were analyzed together with frequently emerged variants T123N, M133I, M133T, M133V, and T143L.
Result: In comparison, T123N and M133I/V/T missed in diagnostic assays presented more altered antigenic index profiles, while T143L showed similar if not lesser degree of changes (Table 1).
Result: These mutation positions corresponded with those of five isolates known to be associated with problem in diagnostic assays and/or escape to vaccine/HBIg therapy: T123N,
Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site.
Abstract: Conversely, coexpression of just the small envelope protein of the M133T mutant could rescue virion secretion.
Abstract: Destroying this site by N131Q/T mutation or preventing glycosylation by tunicamycin treatment of transfected cells abrogated the effect of the M133T mutation.
Abstract: Here we used transcomplementation assay to confirm that the I110M, G119E, and R169P mutations in the S domain of viral envelope proteins impair virion secretion and that an M133T mutation rescues virion secretion of the I110M and G119E mutants.
Abstract: In
A novel nucleotide insertion in S gene of hepatitis B virus in a chronic carrier.
Abstract: S114T, C121Y, T126S/A, Q129K, G130R, T131N, M133T, G145R, N146D substitution and premature stop codon were also found in those clones.
Result: Of 4 clones with wildtype HBsAg, T131N(ACC AAC) and M133T(ATG ACG) substitution occurred in clon17-clone19, also forming a possible N-Linked glycosylation site(figure 2).
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
PMID: 20119580
2010
Journal of Korean medical science
Introduction: In this patient, they detected deletions of nucleotides 23 to 55 (amino acids 12 to 22) in the Pre-S2 region, and amino acid substitutions at I126S, T131N, M133T, and S136Y in the 'a' determinant region of HBsAg.
Reactivation of hepatitis B virus infection with persistently negative HBsAg on three HBsAg assays in a lymphoma patient undergoing chemotherapy.
Abstract: RESULTS: Of 47 serum samples from patients with chronic HBV infection, amino acid mutation in 'a' determinant occurred in 12 samples (25.53%,12/47), correlating with T126A, I126T/S, P127T, T131N, M133L, M133T and T140I; high proportion of mutation clustered in first loop of 'a' determinant (92.86%,13/14), rtV207I mutation in C domain of reverse transcription occured in one sample.
Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.
Discussion: Nevertheless, we have successfully used this approach to identify an G119E mutation in the envelope gene as responsible for impaired virion secretion of an HBV isolate, and also revealed ability of an M133T mutation in the envelope gene of clone 4B to overcome an I110M mutation, which would otherwise block virion secretion.
HBV mutation literature information.
PMID: 
2012
Virology journal
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