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 HBV mutation literature information.


  Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China.
 PMID: 27131009       2016       Journal of infection in developing countries
Abstract: Moreover, one HBV strain in the schizophrenia group presented I126S vaccine escape mutation (5.88%), while three HBV isolates showed Q129H, M133L, and G145R vaccine escape mutations in the control group (6.81%).


  [Variability of Reverse Transcriptase Gene and S Gene in Lamivudine-treated Chronic Hepatitis B Patients].
 PMID: 26524917       2015       Bing du xue bao
Abstract: sM133L and sG145R variants were also present in patients with the YMDD mutation.


  Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.
 PMID: 26457811       2015       PloS one
Result: Amino acid substitutions in the major hydrophilic region predicted from twelve clones of HBV from the father's sample include T115I, T116A, S117G
Result: Five of the twelve substitutions, including T118K, T123N, T131N, M133L and N 145A, are associated with antibody escape.
Result: Two clones have T118K and N145A substitutions, two other clones have T131N and the final clone has M133L (Fig 2).


  Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.
 PMID: 26202119       2015       Journal of clinical microbiology
Abstract: The most frequent MHR variants related to immune evasion in the major and intermediate populations were P120Q/T, T123A, P127T, Q129H/R, M133L/T, and G145R.


  Occult hepatitis B infection among individuals belonging to the aboriginal Nicobarese tribe of India.
 PMID: 25500663       2014       Journal of infection in developing countries
Abstract: Single or multiple amino acids substitutions were found in 5 of 34 samples (14.7%) which includes I110T, P120T, P/T127I, A128P, M133L and G159V.


  [Clinical significance of hepatitis B virus S gene mutation for recurrence of hepatitis B after liver transplantation].
 PMID: 25243957       2014       Zhonghua gan zang bing za zhi
Abstract: One of the patients had T126I and G145A mutations, and the other had a M 133L mutation.


  Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
 PMID: 24587360       2014       PloS one
Abstract: Furthermore, the frequently occurring mutations in the major hydrophilic loop of the S gene include the T125M, A128V and M133I/L.
Discussion: Several amino acid substitutions within the major hydrophilic loop were observed in our study population which included Y100D, Q101R/H, M103V/I, T125M, A128V, M133L, D144E and G145S.


  Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China.
 PMID: 23951004       2013       PloS one
Discussion: Other common escape mutations, including G145R, D144A, P142S, Q129H, I/T126N/A and M133L, were not found in our OBI isolates.


  Epidemiology of HBV S-gene mutants in the Liguria Region, Italy: Implications for surveillance and detection of new escape variants.
 PMID: 23296324       2013       Human vaccines & immunotherapeutics
Abstract: HBsAg resulted undetectable by 3 of the 8 samples, derived from patients with multiple mutations: T126I-T131A-C139Y-E/D144G, T126I-M133L, and P120Q-T126I.


  "Construction and expression of hepatitis B surface antigen escape variants within the ""a"" determinant by site directed mutagenesis."
 PMID: 24076590       2013       Iranian journal of immunology
1Abstract: RESULTS: Ten HBsAg mutants having single mutation within the ""a"" determinant including P120E, T123N, Q129H, M133L, K141E, P142S, D144A, G145R, N146S and C147S together with a wt form were successfully constructed and expressed in CHO cells."



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