[Heterogeneity of hepatitis B virus and diagnostic potential of modern test systems for the detection of HBsAg].
PMID: 22442974
2012
Zhurnal mikrobiologii, epidemiologii i immunobiologii
Abstract: Amino acid substitutions G145A, M133I, S132T localized in the main hydrophilic region and P217L, S207N, V184A localized in the C-end of the protein C that are connected with diagnostic and vaccine escape were identified in 5 isolates.
Abstract: Approximately equal potential of 6 test systems to detect HBsAg with amino acid substitutions G145A, M133I and S132T localized in the MHR region were shown.
Prediction of conformational changes by single mutation in the hepatitis B virus surface antigen (HBsAg) identified in HBsAg-negative blood donors.
Abstract: RESULTS: Three HBV variants (T123A, M133L and T143M) and a wild type sequence were analyzed together with frequently emerged variants T123N, M133I, M133T, M133V, and T143L.
Discussion: The degree of changes in antigenicity profile
Discussion: The trend in M133I/T/V can also be correlated with the differential amino acid properties, with similar changes between M133I and M133V that involve similarly-sized non polar Met, Ile, and Val; and slightly more significant antigenic alteration in M133T, in which there is a change from Met to polar Thr.
Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B.
PMID: 20382061
2010
International journal of infectious diseases
Abstract: In the treatment-naive group the prevalence was 8.1% (15/185), with the following patterns: sL109I, sI110V, sS117INST, sP120T, sP127T, sM133I, sC137L+sG145R, sS143L.
Frequency of hepatitis B virus 'a' determinant variants in unselected Spanish chronic carriers.
HBV mutation literature information.
PMID: 
2012
Zhurnal mikrobiologii, epidemiologii i immunobiologii
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