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 HBV mutation literature information.


  Dried blood spot sampling for hepatitis B virus quantification, sequencing and mutation detection.
 PMID: 35102169       2022       Scientific reports
Table: M103I


  Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.
 PMID: 33468062       2021       BMC infectious diseases
Table: M103I


  Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
 PMID: 31269905       2019       BMC infectious diseases
Table: M103I


  Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
 PMID: 29408943       2018       PloS one
Table: M103I


  Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.
 PMID: 27182775       2016       PloS one
Table: M103I


  Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression.
 PMID: 25418031       2015       Hepatology (Baltimore, Md.)
Abstract: Of the 13 HBsAg mutations found in these patients, 8 of 13 (M103I-L109I-T118K-P120A-Y134H-S143L-D144E-S171F) reside in a major hydrophilic loop (target of neutralizing antibodies [Abs]); some of them are already known to hamper HBsAg recognition by humoral response.


  Unique surface gene variants of hepatitis B virus isolated from patients in the Philippines.
 PMID: 24009186       2014       Journal of medical virology
Abstract: Unique sequence variants at amino acid positions M103I, L109P, S117R, F134I, and S136L found in this study have not yet been reported.


  Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
 PMID: 24587360       2014       PloS one
Result: In addition, other mutations such as Y100D, Q101R/H, M103V/I, D144E and G145S was also found within the major hydrophilic loop (MHL) of the S gene.
Discussion: Several amino acid substitutions within the major hydrophilic loop were observed in our study population which included Y100D, Q101R/H, M103V/I, T125M, A128V, M133L, D144E and G145S.


  Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro.
 PMID: 22967103       2012       Journal of viral hepatitis
Result: In lysates, HBsAg levels were slightly lower for expression vectors containing the M103I and K122R mutations compared to wild-type (Figures 1B,D).
Discussion: Although the K122R mutation results in a serotype change from 'd' to 'y', both K122R and M103I may have minor effects with respect to protein folding, antigenicity, detection by anti-HBs, and protein expression, due to their location within the antigenic determinant region of HBsAg.
Discussion: First, the specific mutations assessed in this study - M103I, K122R, and G145A - had not been included in previous functional analyses of



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