literature

HBV mutation literature information.

Resistant mutations and quasispecies complexity of hepatitis B virus during telbivudine treatment.

PMID: 26382925 2015 The Journal of general virology

Abstract: Furthermore, double mutations rtL80I/M204I and rtL80V/M204V had replication efficiency similar to that of rtL80I and rtL80V, respectively.

Abstract: However, in contrast with their sensitivity to lamivudine, rtL80I and rtL80V were moderately resistant to LDT.

Abstract: In vitro replication efficiency analyses showed that the RT mutations had different impacts on HBV replication, with a tendency of rt

Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.

PMID: 26322642 2015 PloS one

Introduction: The well-characterized compensatory mutations include rtL180M, rtL80I/V, and rtV173L; they enhance replication of the rtM204I/V mutants.

Discussion: The compensatory mutations discovered thus far in the YMDD mutants include rtL180M, L80I/V, V173L, S117F, and L229F/V.

Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro.

PMID: 26220282 2015 BMC complementary and alternative medicine

Introduction: The L80V/I mutation was first detected in patients with severe hepatitis after apparent LMV failure.

Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.

PMID: 24835494 2014 PloS one

Figure: Described antiviral resistant mutations were highlighted and denoted at the top (e.g., L80V).

[Detection of resistance mutations in chronic hepatitis B patients receiving antiviral therapy for over one year].

PMID: 23971924 2013 Mikrobiyoloji bulteni

Abstract: In five of nine samples primary and compensatory multiple mutations (L180M + M204I in one sample, L80I + L180M + M204I in two samples, L80I/V + M204I in one sample) and primary single mutations associated with LVD resistance (M204I/V) in four samples were detected by Inno-Lipa HBV DRv2.

Detection of lamivudine-resistant variants and mutations related to reduced antigenicity of HBsAg in individuals from the cities of Santos and Sao Paulo, Brazil.

PMID: 24165277 2013 Virology journal

Abstract: The other samples showed only compensatory mutations, such as rtL80F (5.88%), rtL80V (2.94%), rtL82V + rtV207L (2.94%), rtT128P (5.88%), rtT128N/S (2.94%) and rtS219A (5.88%).

Result: The other samples showed only the compensatory mutations rtL80F (5.88%), rtL80V (2.94%), rtL82V

Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B.

PMID: 24160943 2013 Virology journal

Abstract: Among LAM/LdT based therapies, HBV rtM204I was significantly associated with HBV rtL80I/V mutations [rtM204I+rtL80I/V (50.0%, 32/64) vs. rtM204V+rtL80I/V (27.3%,9/33), P=0.032]

Result: Among those rtM204 mutations, a total of 14 types of rtM204 containing mutant patterns were observed, and rtM204I/V+rtL180M (78/106, 73.6%) and

Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B.

PMID: 23710315 2013 Gut and liver

Abstract: Patient 2 had substitutions of L80V, W153Q, and L180M.

Result: At baseline, some colonies contained LAM or ETV resistant mutations such as L80V/I, L180M, M204V/I, A181V, and N236H.

Discussion: LAM compensatory mutations, rtL80V/I and/or rtV173L, were seen in patient 1, 2, 4, and 6.

Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naive chronic HBV patients.

PMID: 23596461 2013 Hepatitis monthly

Result: Common and frequent lamivudine-related amino acid substitutions were found in this study including N53K 3.68% (12/325), L80V/I 3.07% (each 5/325), L82M1.22% (4/325) L91I 7.06% (23/325), T128I 1,53% (5/325), L180M3.37% (11/325), and M204I2.76%(9/325) M204V 1.23% (4/325) see Figure 1.

Table: L80V

Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population.

PMID: 23409946 2013 Virology journal

Abstract: Notably, classical antiviral resistance mutations (rtL80I/V-rtI169T-rtV173L-rtL180M-rtA181T/V/S-rtT184A/S/G/C-rtA194T-rtS202C /G/I -rtM204V/I-rtN236T-rtM250V) were n

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