literature

HBV mutation literature information.

Hepatitis B Virus Genotypes and Antiviral Resistance Mutations in Romanian HIV-HBV Co-Infected Patients.

PMID: 35454370 2022 Medicina (Kaunas, Lithuania)

Abstract: The most frequently encountered RAMs are M204V/I: 48.8%, L180M: 33.3%, L80V: 28.8%, and V173L: 42.2%.

Abstract: There are no significant differences in the distribution of RAMs in patients infected with different HBV genotypes, except for the L80V and N236T mutations, which were more frequently found in HBV genotype A infections (p = 0.032 and p = 0.004, respectively).

Result: M204V/I: 48.8%, plus L180M: 33.3% +- L80V: 28.8% and V173L: 42.2%:a profile suggestive for LAM resistance (with all mutations, except for M204V, also being associated with telbivudine resistance, and the co

Reactivation of Occult Hepatitis B Virus Infection During Long-Term Entecavir Antiviral Therapy.

PMID: 35359734 2022 Frontiers in microbiology

Table: L80V

High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy.

PMID: 33986897 2021 The Canadian journal of infectious diseases & medical microbiology

Result: RtM204I/V + rtL80I/V and rtM204I + rtA181 T/V may affect the sensitivity to LAM, TBV, and ADV; they also presented but the proportions of the mutations were low (Table 3).

Result: At the compensatory mutation sites, 15.1% (11/73) participants had L80I/V mutation that is associated with resistance to LAM.

Discussion: Furthermore, some pregnant women had multibase mutations combined with rtM204I/V at baseline, including rtM204I + rtA181 T/V,

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Method: ETV resistance: Two or more amino acid substitutions are required across the HBV RT protein to confer resistance to ETV which could occur as a combination of M204I/V with one or more of the following substitutions L80I/V, I163V, I169T, V173L, L180M, A181S/T/V, T184X, A186T, S202C/G/I/R, M250I/V and/or C256S/G.

Result: Genotype C had the highest prevalence of all of these mutations, apart from L80I/M/V which is most common in Genotype

Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.

PMID: 32765014 2020 Infection and drug resistance

Abstract: Primary and secondary DR variants were found in 7.3% (15/206) of patients, including rtL80I/V, rtI169T, rtV173L rtL180M, rtA181T/V, rtM204I/V, and rtN236T.

Result: Primary and/or secondary DR variants were found in 7.3% (15/206) of patients, and included rtL80I/V, rtI169T, rt

PMID: 32915862 2020 PloS one

Discussion: Resistance to lamivudine is best recognized in association with the rtM204V/I mutation, which is also associated with decreased viral replication fitness, leading to the subsequent selection of the compensatory mutants rtL180M, rtV173L, and rtL80I/V.

Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan.

PMID: 30867996 2019 PeerJ

Discussion: M204I/V mutations are frequently accompanied by compensatory mutations in other domains such as 59 rtV173L, rtL180M, rtT184S/G, 58 rtI169T, rtS202I, rtL80V/I and rtQ215S which enhanced the replication efficiency of rt204I/V mutants without significantly affecting lamivudine resistance, by compensating the decrease in efficiency due to resistance-associated changes.

Naturally occurring core protein mutations compensate for the reduced replication fitness of a lamivudine-resistant HBV isolate.

PMID: 30902704 2019 Antiviral research

Introduction: However, compensatory mutations have been reported to partially restore the viral replication capacity, including rtL80V/I, rtL82M, rtV173L and rtV207I, mostly in the RT region of pol.

Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy.

PMID: 30906435 2019 Experimental and therapeutic medicine

Result: Common and frequent mutations identified in the cohort of the present study included rtL80V/I, rtV84M, rtL91I, rtN118H/D/T, rtT128A, rtL180M, rtT184L/S/A, rtV191I, rtS202G, rtV207I/M, rtS213T

Frequency of Hepatitis B Virus Resistance Mutations in Women Using Tenofovir Gel as Pre-Exposure Prophylaxis.

PMID: 31248149 2019 Viruses

Result: No mutations known to cause tenofovir resistance (L180M, A181I/V, A194T, M204V/I, V214A, Q215S, N236T) or lamuvudine (3TC) resistance (L80V/I, I169T, V173L, L180M, A181T, T184S, M204V/I/S, Q215S) were observed.

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