literature

HBV mutation literature information.

Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.

PMID: 26322642 2015 PloS one

Introduction: The well-characterized compensatory mutations include rtL180M, rtL80I/V, and rtV173L; they enhance replication of the rtM204I/V mutants.

Discussion: The compensatory mutations discovered thus far in the YMDD mutants include rtL180M, L80I/V, V173L, S117F, and L229F/V.

Resistant mutations and quasispecies complexity of hepatitis B virus during telbivudine treatment.

PMID: 26382925 2015 The Journal of general virology

Abstract: Furthermore, double mutations rtL80I/M204I and rtL80V/M204V had replication efficiency similar to that of rtL80I and rtL80V, respectively.

Abstract: However, in contrast with their sensitivity to lamivudine, rtL80I and rtL80V were moderately resistant to LDT.

Abstract: In vitro replication efficiency analyses showed that the RT mutations had different impacts on HBV replication, with a tendency of rt

[Variability of Reverse Transcriptase Gene and S Gene in Lamivudine-treated Chronic Hepatitis B Patients].

PMID: 26524917 2015 Bing du xue bao

Abstract: rtL80I was present in most of the patients with rtM204I (14/20, 70%).

Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.

PMID: 24788140 2014 PloS one

Result: It is worth noting that we did not observe any of the common NA-related resistance mutations including rtM204V/I, rtS202C/G/I, rtL180M, rtA181T/V, rtT184A/I/L/G/C/M, rtA194T, rtI169T, rtV173L, rtL80I, rtN236T, and

PMID: 24586482 2014 PloS one

Introduction: Compensatory mutations rtL180M, rtV173L, and rtL80I to LAM are often co-selected to restore viral replication efficacy.

Substitution rtq267h of hepatitis B virus increases the weight of replication and Lamivudine resistance.

PMID: 24348637 2013 Hepatitis monthly

Discussion: Due to selection advantage under high selection pressure of LMV or LdT, HBV virions with rtM204V/I, especially together with rtL180M and/or rtL80I and/or rtV173L at the same time, would be selected as dominant strains.

Discussion: Substitutions rtL180M /rtL80I/rtV173L which can restore the impaired HBV replication ability, are called adaptive mutations of HBV to LMV.

Death from Liver Failure despite Lamivudine Prophylaxis during R-CHOP Chemotherapy due to Rapid Emergence M204 Mutations.

PMID: 25374716 2013 Case reports in hepatology

Abstract: ALT 902 IU/L, HBeAg negative, HBV DNA 1.02E8 IU/mL, and genotyping confirmed L80I, M80V, and M204V/S mutations.

Abstract: Four months after chemotherapy, despite ongoing LAM of 7-month duration with confirmed adherence, severe asymptomatic hepatitis was noted during routine monitoring with ALT 1019 IU/L, HBeAg negative, HBV DNA 1.43E7 IU/mL, and genotyping confirmed L80I and M204I mutations.

Conclusion: HBeAg

Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B.

PMID: 24160943 2013 Virology journal

Abstract: Among LAM/LdT based therapies, HBV rtM204I was significantly associated with HBV rtL80I/V mutations [rtM204I+rtL80I/V (50.0%, 32/64) vs. rtM204V+rtL80I/V (27.3%,9/33), P=0.032]

Result: Among those rtM204 mutations, a total of 14 types of rtM204 containing mutant patterns were observed, and rtM204I/V+rtL180M (78/106, 73.6%) and

[Detection of resistance mutations in chronic hepatitis B patients receiving antiviral therapy for over one year].

PMID: 23971924 2013 Mikrobiyoloji bulteni

Abstract: In five of nine samples primary and compensatory multiple mutations (L180M + M204I in one sample, L80I + L180M + M204I in two samples, L80I/V + M204I in one sample) and primary single mutations associated with LVD resistance (M204I/V) in four samples were detected by Inno-Lipa HBV DRv2.

Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B.

PMID: 23710315 2013 Gut and liver

Abstract: L80I and V173L were also identified in patient 6.

Result: At baseline, some colonies contained LAM or ETV resistant mutations such as L80V/I, L180M, M204V/I, A181V, and N236H.

Discussion: LAM compensatory mutations, rtL80V/I and/or rtV173L, were seen in patient 1, 2, 4, and 6.

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