literature

HBV mutation literature information.

Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.

PMID: 28392234 2017 Journal of hepatology

Discussion: However, we did not observe associated rtL80I substitutions by sequencing in our cases.

Discussion: In this regard, the rtL80I was shown to be associated with restoring viral replication and increasing drug resistance properties of LAM-resistant isolates with impaired replication.

HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.

PMID: 28303969 2017 Scientific reports

Introduction: Primary LMV resistance mutation has been mapped in the reverse transcriptase (RT) domain of HBV Pol and typically involved rtM204I/V, while compensatory mutations rtL180M, rtV173L, and rtL80I are often co-selected during therapy to restore HBV replication efficacy.

Result: After implementing Benjamini-Hochberg correction, 3 (rtM204I, rtL80I, rtY54H) out these 7

HIV therapy with unknown HBV status is responsible for higher rate of HBV genome variability in Ethiopia.

PMID: 27354181 2017 Antiviral therapy

Abstract: RESULTS: In 34 out of 161 study subjects (21.1%) HBV drug resistance mutations (DRMs) were detected with a frequency of 3.1% rtL80F/I, 0.6% rtA181V, 1.2% rtT184S, 6.2% rtV173L, 10.6% rtL180M, 10.6% rtM204V/I and 8.1% rtI233V.

HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.

PMID: 27167598 2017 Antiviral therapy

Discussion: In our study, twenty (95.2%) of the 21 patients had at least one mutation that may confer clinical resistance to both telbivudine (rtM204V/I) and 3TC (rt180M + rtM204V/I, rtV173L + rtL180M + rtM204V/I, and rtL80I + rtM204I).

Discussion: The 3TC mutations rtL80I, rtV173L,

PMID: 27694733 2016 Journal of infection in developing countries

Abstract: Among patients who harbored rtM204 combination mutations, rtM204I and rtM204V were significantly associated with rtL80I/V and rtL180M, respectively.

Evaluation of the dynamic pattern of viral evolution in patients with virological breakthrough during treatment with nucleoside/nucleotide analogs by ultradeep pyrosequencing.

PMID: 26648309 2016 Molecular medicine reports

Abstract: Treatment with lamivudine resulted in an increased rate of the viral mutations, rtM204V/I, rtL180M and rtL80I.

Result: Notably, the mutation rate of rtM204I/V was markedly increased at the time of virological breakthrough in eight patients, and this was accompanied by an increased mutation rate of rtL180M and/or rtL80I/V.

[Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology].

PMID: 26983387 2016 Zhonghua gan zang bing za zhi

Abstract: Each of the NAs had dominant drug-resistant mutational profiles, with rtM204I+rtL180M+-rtL80I (30.9%) for LAM, rtA181T/N (21.3%), rtS213T/N (21.3%) and rtV214A (21.3%) for ADV, rtl180M (48%) for ETV, rtM204I for LdT, and rtA194T for tenofovir disoproxil fumarate (TDF).

Mutational analysis of reverse transcriptase and surface proteins of patients with partial virological response during mono and combination antiviral therapies in genotype D chronic hepatitis B.

PMID: 27504160 2016 Electronic physician

Abstract: T54N, L80I/V, I91L/V, L180M, M204I/V, Q215P/S, and F221Y/S showed the highest number of mutations in all groups with different frequencies.

Result: L80I/V was found at the frequencies of 40 and 25% in groups I and III, respectively.

Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro.

PMID: 26220282 2015 BMC complementary and alternative medicine

Introduction: The L80V/I mutation was first detected in patients with severe hepatitis after apparent LMV failure.

Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.

PMID: 26322642 2015 PloS one

Introduction: The well-characterized compensatory mutations include rtL180M, rtL80I/V, and rtV173L; they enhance replication of the rtM204I/V mutants.

Discussion: The compensatory mutations discovered thus far in the YMDD mutants include rtL180M, L80I/V, V173L, S117F, and L229F/V.

Browser Board

Co-occurred Entities

Filtrator