Discussion: HBV variants with combinations of HBs Ag (G145R or P120T) and polymerase (L526M plus M550V) mutations showed increased HBV replication resulting in a severe clinical course in transplanted patients.
Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative.
Abstract: The lamivudine-resistant HBV, L526M/M550V double mutant strain, was also sensitive to helioxanthin and 5-4-2.
[A study on detection method of lamivudine related mutations in hepatitis B virus polymerase gene].
PMID: 15340520
2004
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: Mutation in the tyrosine methionine aspartic aspartic acid (YMDD) motif of HBV polymerase gene was found in eight patients and mutations of YMDD motif associated with L526M were found in another three patients.
Hepatitis B virus variants in an HIV-HBV co-infected patient at different periods of antiretroviral treatment with and without lamivudine.
Discussion: It is believed that the L526M mutation, when not accompanied with a mutation in the YMDD motif, does not confer lamivudine resistance.
Discussion: More rarely, HBV variant presenting M550S replacement may be selected during lamivudine treatment The M550V variant may be accompanied by a mutation (leucine to methionine) at position 526.
Discussion: The triple mutation V519L, L526M, M550V causes the concomitant amino acid substitutions E164D and I195M in the small S protein.
Reverse transcriptase activity of hepatitis B virus (HBV) DNA polymerase within core capsid: interaction with deoxynucleoside triphosphates and anti-HBV L-deoxynucleoside analog triphosphates.
Abstract: The L526M and M550V mutations caused a greater decrease in the Vmax using the wt RNA template compared with the G1896A-mutated template.
Abstract: The L526M, M550V, and L526M/M550V mutations caused varying degrees of resistance to the different M-nucleoside triphosphates.
Abstract: The additional L526M mutation increased the efficiency of the M550V-mutated DP but no more than that of the L526M-mutated DP.
Abstract: The use of L(-)SddC [beta-L-2',3'-dideoxy-3'-thiacytidine (lamivudine, 3TC)] for the treatment of Herpes B virus (HBV) infection is hindered by the emerge
Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy.
1Abstract: These mutations caused L426I/L526M/M550I triple mutation (equivalent to L428I/L528M/M552I in previous reports) in the polymerase, and D144E mutation in the ""a"" determinant of HBsAg."
Abstract: Our study suggests that mutations in the HBsAg (D144E) and the polymerase (L426I/L526M/M550I) of HBV genome may be responsible for viral breakthrough despite HBIG prophylaxis and lamivudine therapy.
[Analysis of three lamivudine-resistant HBV mutants with the method of restriction enzyme digestion and its application].
PMID: 12870011
2003
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: Six of them were infected with M5501 mutant; five were infected with M550V mutant (one of them had both M550V and L526M mutations).
"Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the ""fingers"" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene."
Abstract: The two most common LMV-resistant mutants produce changes in the viral polymerase protein (rt) of rtM204I and rtL180M/M204V (previously rtM550I and rtL526M/M550V).
Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy.
Abstract: Mutations in the YMDD motif of the DNA polymerase gene were identified in 11 patients (3 with M550V/I mutation; 7 with M550V/I and L256M mutations; 1 with M550V/I, L526M and V519L mutations).
HBV mutation literature information.
PMID: 
2021
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