Result: The point-mutations on the S gene that owned the rates of >30% of the population were: S53L (37.7%), A184V/G (39.3%), and S210K/N/R/S (39.3%); from 15 to <30% were L21S (29.1%), G44E/V (18.6%), I126T/N/S (21.1%), and M198I/M (18.2%); and from 5 to <15% were V14A/G/Q (10.1%), N40S/K (6.9%), T47A/E/V/K (9.3%), P/L49R/H (5.7%), P62Q/L (9.7%), C76Y/T/W (10.5%), Y100C/F
Molecular and serological characterization of occult hepatitis B among blood donors in Maputo, Mozambique.
PMID: 32997000
2020
Memorias do Instituto Oswaldo Cruz
Table: L49R
Clinical Outcome and Viral Genome Variability of Hepatitis B Virus-Induced Acute Liver Failure.
Abstract: Amino acid deletions (del; 16-22 and 20-22) in preS2 and SHB mutation L49R were exclusively detected in patients with ALF-NSR.
High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: Virological characteristics associated with poor immune clearance.
Result: A similar situation was observed also for patients 2 and 3, and it was characterized by specific mutational profiles (L49R+S193L and G102A/G+S193S/L+S210S/R+L216 stop) observed only in plasma and not in liver tissue (Fig 3).
Hepatitis B virus genotype E surface antigen detection with different immunoassays and diagnostic impact of mutations in the preS/S gene.
PMID: 17503077
2007
Medical microbiology and immunology
Abstract: DNA positive samples with no detectable HBsAg or reduced HBsAg detection signals (<75% of mean signal obtained with HBsAg positive samples) revealed several mutations (V14A, F46S, N48T, L49R, I49T, D51G, A53V, P54L, Q82P, F83C, L127P, A184V, T189I, S204N, V224A), mostly outside the a-determinant.
HBV mutation literature information.
PMID: 
2022
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