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 HBV mutation literature information.


  Identification and Characterization of Besifovir-Resistant Hepatitis B Virus Isolated from a Chronic Hepatitis B Patient.
 PMID: 35203489       2022       Biomedicines
Abstract: The ten mutations include rtV23I (I), rtH55R (R), rtY124H (H), rtD134E (E), rtN139K (K), rtL180M (M), rtM204V (V), rtQ267L (L), rtL269I (I) and rtL336M (M).
Result: When compared to the WT, Clone 1-1 harbored 10 mutations (IRHEKMVLIM: rt


  Characterization of Hepatitis B virus polymerase mutations A194T and CYEI and tenofovir disoproxil fumarate or tenofovir alafenamide resistance.
 PMID: 32894807       2021       Journal of viral hepatitis
Abstract: Both the A194T and a quadruple mutation CYEI (S106C, H126Y, D134E and L269I) in hepatitis B virus (HBV) polymerase reverse transcriptase domain (pol/RT) are suggested to be associated with treatment failure with tenofovir disoproxil fumarate (TDF).


  Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir.
 PMID: 33462964       2021       Hepatology research
Abstract: A recent Korean report showed tha
Abstract: Four mutations (rtS106C, rtD134N/S[N/S], rtM204V, and rtL269I) plus ETV resistance (rtL180M and rtS202G) existed when she developed viral breakthrough during ETV and TDF combination therapy in April 2013.
Abstract: Moreover, three mutations (rtS106C, rtD134N, and rtL269I) existed at baseline.


  Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.
 PMID: 33562603       2021       International journal of molecular sciences
Method: Two clones (CYEI: rtS106C (C) + rtH126Y (
Discussion: Nevertheless, some recent studies have shown that rtS78T/sC69*, rtS106C/rtH126Y/rtD134E/rtL269I, and rtL180M/T184L/M204V/rtA200V are related to TDF resistance.


  Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.
 PMID: 32994690       2020       World journal of gastroenterology
Introduction: In addition, rtS106C+rtH126Y+rtD134E+rtL269I quadruple mutations have recently been reported to confer TDF resistance.


  Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.
 PMID: 30794889       2019       Journal of hepatology
Abstract: RESULTS: Five mutations (rtS106C [C], rtH126Y [Y], rtD134E [E], rtM204I/V, and rtL269I [I]) were commonly found in viral isolates from 2 patients.


  Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice.
 PMID: 30866789       2019       Emerging microbes & infections
Introduction: Moreover, HBV rtL269I and rtS78 T/sC69stop mutations were respectively reported being associated with enhanced viral replication of LAMr mutants and insufficient response to ETV treatment.


  Occult HBV Infection in Immunized Neonates Born to HBsAg-Positive Mothers: A Prospective and Follow-Up Study.
 PMID: 27835694       2016       PloS one
Table: L269I


  Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.
 PMID: 26322642       2015       PloS one
Result: When the rtL269I mutation was added to the YMDD mutants, the relative replication levels (no drug vs LMV or ETV treatment) of none of the artificial mutants were significantly altered by LMV (Fig 3A and 3B) or ETV treatment (Fig 4A and 4B).
Discussion: Approximately 2-, 3-, 4-, and 7-fold higher replication capacity was observed when the rtL269I mutation was introduced to WT, rt Discussion: However, among the 16 patients in whom the YMDD mutation was detectable during antiviral treatment, 7 (43.8%) displayed the rtL269I substitution along with rtM204I/V mutation (Table 1).



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