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 HBV mutation literature information.


  Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China.
 PMID: 26612031       2015       Scientific reports
Introduction: Two large-scale clinical studies from China found that rtM204I with or without rtL180V was more frequent in genotype C than genotype B.


  Drug-resistance associated mutations in polymerase (p) gene of hepatitis B virus isolated from malaysian HBV carriers.
 PMID: 24497877       2014       Hepatitis monthly
Abstract: A number of significant drug resistant mutations were found in five patients including S202I, N236T, M250L, L180M/V, M204I, A181T, T184G, M250V, and V173L.
Abstract: Of these, L180M/V and M204I were most frequently detected (80%) and associated with lamivudine in combination with emtricitabine and telbivudine drug resistance.
Result: Based on sequence analysis, patient 839920, a 76-year-old male, showed the presence of L180V, M204I, and V173L mutations in


  [Lamivudine and adefovir resistance in a patient with HBeAg negative chronic hepatitis B].
 PMID: 16448607       2006       Gastroenterologia y hepatologia
Abstract: We have studied a 49-year-old patient with a HBeAg-negative chronic hepatitis B in whom, after 34 months of treatment with lamivudine and associated with an increase in the serum hepatitis B virus (HBV) DNA, the lamivudine resistance mutations M204I and L180V were detected.



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