Mutational patterns of hepatitis B virus genome and clinical outcomes after emergence of drug-resistant variants during lamivudine therapy: analyses of the polymerase gene and full-length sequences.
Abstract: Baseline characteristics, alanine aminotransferase (ALT) levels, and HBV DNA levels within 6 months after the emergence of YMDD variants did not differ significantly between patients with rtM204I alone and those with rtL180M/rtM204V.
Abstract: During long term follow-up, the addition of rtL180M to rtM204I was found in four patients 7-31 months after detecting the change at rt204 and was linked to increased ALT levels.
Abstract: The rtM204V mutations were always accompanied by mutatio
Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay.
PMID: 17913933
2007
Journal of clinical microbiology
Abstract: In all 20 patients, the mutation occurred in the YMDD motif at reverse transcriptase position 204 (rt204; M204V/I) either with or without the compensatory mutation at position rt180 (L180M).
Successful treatment of an entecavir-resistant hepatitis B virus variant.
Abstract: Direct sequence analysis of the ETV-resistant strain showed appearance of amino acid substitution rtS202G in the reverse transcriptase (RT) domain, together with rtL180M + M204V substitution that had developed at the emergence of LAM-resistant mutant.
Abstract: In conclusion, this study showed that virological and biochemical breakthrough due to ETV could occur in patients infected with LAM-resistant HBV and confirmed that the addition of rtS202G substitution to the rtL180M + M204V mutant strain is responsible for ETV resistance and we could treat the resistant
Hepatitis B virus genotypes circulating in Brazil: molecular characterization of genotype F isolates.
Result: One (209-CW) displayed the double rtL180M-rtM204V lamivudine-resistance mutation and the other (043-N) showed an additional rtV173L mutation,
Table: L180M
Discussion: The frequent lamivudine-resistance rtL180M-rtM204V double mutation was detected in two isolates (043-N and 209-CW), while a third isolate (043-N) displayed a rare rtV173L-rtL180M-rtM204V triple mutation (Table 2).
Selection of hepatitis B virus (HBV) vaccine escape mutants in HBV-infected and HBV/HIV-coinfected patients failing antiretroviral drugs with anti-HBV activity.
PMID: 18167643
2007
Journal of acquired immune deficiency syndromes (1999)
Abstract: The triple-HBV mutant rtV173L + rtL180M + rtM204V, which has been shown to produce a diminished hepatitis B surface (HBs) antigen-antibody binding, was found in 3 individuals, all coinfected with HIV and HBV.
[HBV gene variants and polymerse gene mutations in children with chronic hepatitis B in the course of the antiviral therapy].
Abstract: YIDD mutation appeared to be the single one in the viral polymerase gene, while YVDD mutations in four patients were accompanied by other changes at amino acid sequence of the HBV polymerase: rtL180M, rtN124D and rtL164M.
Genotypic resistance to lamivudine among hepatitis B virus isolates in Mexico.
PMID: 16373428
2006
The Journal of antimicrobial chemotherapy
Abstract: The isolate from the hepatitis patient showed a double mutation at codon positions 180 (L180M) and 204 (M204V), thus a 2.6% prevalence of genotypic resistance to lamivudine was found.
Abstract: The isolate from the haemodialysis patient showed a single mutation at codon position 180 (L180M).
Successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant HBV mutant.
Conclusion: Sequencing of the HBV polymerase revealed two common lamivudine resistant mutations -
Introduction: However, new adefovir-resistant mutations have been reported, such as the rtA181V mutation which is closely located to the rtL180M mutation conferring resistance to lamivudine.
Discussion: reported recently decreased in vitro susceptibility to both tenofovir and adefovir of two HBV resistant mutants (N236T adefovir and L180M + M204V + N236T lamivudine/adefovir resistant strains).
Inhibition of hepatitis B virus (HBV) replication by pyrimidines bearing an acyclic moiety: effect on wild-type and mutant HBV.
PMID: 16539393
2006
Journal of medicinal chemistry
Abstract: These compounds were also found to retain sensitivity against lamivudine-resistant HBV containing a single mutation (M204I) and double mutations (L180M/M204V).
Characteristics of drug resistant HBV in an international collaborative study of HIV-HBV-infected individuals on extended lamivudine therapy.
Abstract: The triple polymerase mutant (rtL173V, rtL180M, rtM204V), which behaves as a vaccine escape mutant in vitro, occurred in 17% of viraemic patients.
HBV mutation literature information.
PMID: 
2007
Journal of medical virology
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