literature

HBV mutation literature information.

Generation of stable cell lines expressing Lamivudine-resistant hepatitis B virus for antiviral-compound screening.

PMID: 12760870 2003 Antimicrobial agents and chemotherapy

Abstract: HBV produced by these cell lines was shown to have a marked decrease in sensitivity to lamivudine, with 450- and 3,000-fold shifts in the 50% inhibitory concentrations for the rtM204I and rtL180M/M204V viruses, respectively, compared to that for the wild-type virus.

Abstract: Replication-competent HBV constructs containing the reverse transcriptase domain L180M/M204V and M204I (rtL180M/M204V and rtM204I) mutations associated with lamivudine resistance were used to produce stable cell lines t

Characterization of hepatitis B virus surface antigen and polymerase mutations in liver transplant recipients pre- and post-transplant.

PMID: 12780567 2003 American journal of transplantation

Abstract: Significant viral polymerase mutations (rtL180M and rtM204I/V) also emerged in all of these patients following treatment with lamivudine and/or famciclovir.

YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine.

PMID: 12823591 2003 Journal of viral hepatitis

Abstract: In addition, this new variant had the rtL180M mutation and a 12 base pair deletion in the pre-S1 region between nucleotides 43-54.

Abstract: In conclusion, the results indicate that, in addition to a Met --> Val and Met --> Ile change in YMDD, a Met --> Ser change at rt204 (YMDD --> YSDD) associated with the rtL180M change can also emerge during lamivudine treatment, which confers lamivudine resistance in vivo and in vitro, leading to virological breakthrough and ALT increases.

Abstract: Of the seven patients, six were HBeAg positive at baseline, and four had a double mutation consisting of rt

Prevalence and characterization of lamivudine-resistant hepatitis B virus mutations in HIV-HBV co-infected individuals.

PMID: 12853747 2003 AIDS (London, England)

Abstract: Unique mutations were detected in HBV polymerase, including rtV173L plus rtL180M plus rtM204V, which occurred in three patients.

The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro.

PMID: 14557667 2003 Journal of virology

Abstract: A second mutation, rtL180M, was previously reported to partially restore replication fitness as well as to augment drug resistance in vitro.

Abstract: In these patients, rtV173L was invariably found as a third mutation in conjunction with rtL180M and rtM204V.

Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient.

PMID: 14642631 2003 Journal of hepatology

Abstract: RESULTS: Sequence analyses of the HBV polymerase gene revealed a sequential selection of lamivudine resistance mutations L180M+M204V, followed by a reversion to wild-type, and subsequently the selection of a novel adefovir resistance mutation N236T.

Monitoring the emergence of hepatitis B virus polymerase gene variants during lamivudine therapy in human immunodeficiency virus coinfected patients: performance of CLIP sequencing and line probe assay.

PMID: 14760897 2003 Antiviral therapy

Abstract: Interestingly, TRUGENE sequencing identified on late samples from three patients a variant carrying rtV173L plus rtL180M plus M204V mutations, having the in vitro characteristics of 'vaccine escape' mutants.

Lamivudine therapy of chronic hepatitis B in three groups of patients: non transplanted patients, liver recipients, and kidney recipients.

PMID: 11938042 2002 Gastroenterologie clinique et biologique

Abstract: After the development of lamivudine resistance, mutations rtM204V and rtL180M were detected in all studied patients, mutation rtM207I in one, with similar results from traditional nucleotide sequencing and a commercial line probe assay.

"Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the ""fingers"" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene."

PMID: 12167344 2002 Virology

Abstract: The LMV-resistant HBV mutants rtM204I and rtL180M/M204V produced substantially weaker HBV DNA replicative intermediate signals by Southern blot analysis and less total intracellular HBV DNA by real-time PCR compared to wild-type virus.

Abstract: The two most common LMV-resistant mutants produce changes in the viral polymerase protein (rt) of rtM204I and rtL180M/M204V (previously rtM550I and rtL526M/

Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy.

PMID: 12171302 2002 Journal of medical microbiology

Abstract: The mutation was followed by a leucine to methionine change at position 180 (rtL180M).

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