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 HBV mutation literature information.


  Lamivudine resistance mutations in European patients with hepatitis B and patients co-infected with HIV and hepatitis B.
 PMID: 21915864       2011       Journal of medical virology
Abstract: LAM substitution mutations L180M + M204V/I were found in six out of seven cases, with an accompanying V173L mutation in three cases.


  Characterization of drug-resistance mutations in HBV D-genotype chronically infected patients, naive to antiviral drugs.
 PMID: 21920388       2011       Antiviral research
Abstract: HBV reverse-transcriptase (RT) region was sequenced and analyzed for 20 mutations, confirmed by in vitro studies as associated with resistance to nucleos(t)ide HBV-RT inhibitors (rtL80I/V-rtI169T-rtV173L-rtL180M-rtA181T/V/S-rtT184A/S/G/C-rtA194T-rtS202C/G/I-


  Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B.
 PMID: 21933446       2011       BMC cancer
Introduction: The rtL180M mutation usually occurs concurrently with the rtM204V mutation and serves as a compensatory mutation.
Method: The methods to detect HBV basal core promoter (BCP) A1762T/G1764A mutations, precore stop codon G1896A mutation, rtM204I mutation, rtM204V mutation, rtL180M mutation were described previously.
Table: L180M


  Molecular epidemical characteristics of Lamivudine resistance mutations of HBV in southern China.
 PMID: 21959623       2011       Medical science monitor
Abstract: The pattern of rtM204I alone was predominantly observed (36.26%, 33/91), followed by rtM204V+rtL180M (23.08%, 21/91).
Result: It is obvious that the pattern of rtM204I alone was dominantly observed (36.26%), followed by rtM204V + rtL180M (23.08%), while other mutation patterns were rare.
Discussion: Other mutations and mixed combinations were also observed (rtM204I+rtV207M/L, r


  [Identification the relationship between mutation patterns of rtM204I/V in the polymerase gene and genotypes of hepatitis B virus].
 PMID: 22053371       2011       Zhonghua gan zang bing za zhi
Abstract: The rtM204V-rtL180M mutations were more frequently found in subgenotype B2 than in subgenotype C2 while the rtM204V-rtL180M-rtV173L mutations were more associated with subgenotype C2 (P < 0.01).


  [Evolution of hepatitis B virus quasispecies during antiviral therapy in one chronic hepatitis B patient].
 PMID: 22152243       2011       Zhonghua gan zang bing za zhi
Abstract: RESULTS: Three mutation patterns detected during antiviral therapy in the patient: rtM204V, rtM204V+rtL180M and rtM204I.


  Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa.
 PMID: 22195774       2011       BMC research notes
Abstract: One patient showed the M204V+ L180M+ V173L+ triple mutation associated with a vaccine escape phenotype, which could be of public health concern in a country with a national HBV vaccination programme.
Result: The M204V mutation was always accompanied by the mutation L180M.
Result: The virus from patient 12 had an S219A mutation, which reverted to the wild-type when 3TC resistance mutations V173L, L180M and M204V were acquired.


  Frequency and mutation patterns of resistance in patients with chronic hepatitis B infection treated with nucleos(t)ide analogs in add-on and switch strategies.
 PMID: 22224083       2011       Hepatitis monthly
Discussion: High levels of ETV resistance resulted from dual rtM250V and rtI169T mutations, and we detected another profile, the rtM204I/V + rtL180M + rtT184A/I/S or rtS202C triple mutation, as an ETV-resistant mutation in both NUC therapy strategies.
Discussion: In the current study, we found 1 patient with dual ADV (rtN236T + rtQ215H) and LAM (rt


  [The mutation patterns of HBV P gene and genotyping in patients with lanivudine-resistant chronic hepatitis B].
 PMID: 22338219       2011       Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: YMDD mutations happened in 100%, only YMDD mutation were 43 patients, while others were YMDD combined with rtL180M mutations; the HBV genotype among 107chronic hepatitis was mainly B (25.2%) and C (73.8%) and only 1 patient was happend B and C mixed infection.
Abstract: Genetype C was mainly YMDD combined with rtL180M mutations pattern, the rate is 60.7% (48/79); while genetype B was mainly rtM204 mutation pattern, the rate is 66.7% (18/27); there were significant difference between the genetype B and C in mutation pattern (chi2 = 8.4, 7.2, respectively, P < 0.


  Monitoring of therapy in patients with chronic hepatitis B virus.
 PMID: 19550344       2010       European journal of gastroenterology & hepatology
Abstract: In the viral response to treatment, three patients developed substitutions at rtM204I associated with LAM resistance and one of these patients presented rtM204V/I plus rtL180M mutation.



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