literature

HBV mutation literature information.

[Variability of Reverse Transcriptase Gene and S Gene in Lamivudine-treated Chronic Hepatitis B Patients].

PMID: 26524917 2015 Bing du xue bao

Abstract: rtL180M coexisted with rtM204V (5/5, 100%).

A Nanoscale Mutation-Sensitive On/Off Switch Based Assays for the Detection of Hepatitis B Virus Lamivudine-Resistant Mutations.

PMID: 26505028 2015 Journal of nanoscience and nanotechnology

Abstract: The purpose of this study was to develop methods for detecting the mutations of YMDD, rtL180M, and rtV173L by nanoscale mutation-sensitive switch consisting of high fidelity polymerase and phosphorothioate-modified allele specific primers.

A novel pyridazinone derivative inhibits hepatitis B virus replication by inducing genome-free capsid formation.

PMID: 26349829 2015 Antimicrobial agents and chemotherapy

Abstract: Both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant were as susceptible to 3711 as wild-type HBV.

Mechanism of Adefovir, Tenofovir and Entecavir Resistance: Molecular Modeling Studies of How A Novel Anti-HBV Agent (FMCA) Can Overcome the Drug Resistance.

PMID: 26336997 2015 Current medicinal chemistry

Abstract: In this regard, homology modeled structure of HBV polymerase was used for minimization, conformational search and Glide XP docking followed by binding energy calculation on wild-type as well as on mutant HBV-polymerases (N236T, L180M+M204V+S202G & A194T).

Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.

PMID: 26322642 2015 PloS one

Introduction: The well-characterized compensatory mutations include rtL180M, rtL80I/V, and rtV173L; they enhance replication of the rtM204I/V mutants.

Introduction: They include rtI169T, rtL180M, rtS184S/A/I/L/G/C/M, M204I/V, rtS202G/I, and rt

Table: L180M

Detection and analysis of resistance mutations of hepatitis B virus.

PMID: 26309637 2015 International journal of clinical and experimental medicine

Abstract: L180M, M204I and M204V were associated with the resistance to lamivudine and telbivudine; L180M, M204I, M204V and V173L were associated with the resistance to entecavir; A181T, N236T and N/H238T were related to the resistance to adefovir.

Abstract: Of multi-base mutations, L180M combined M204V had a high prevalence and were frequently found in patients with resistance to lamivudine and telbivudine.

Abstract: Of single base mutation, L180M, M204I, M

YMDD Motif Mutation Profile Among Patients Receiving Liver Transplant Due to Hepatitis B Virus Infection With Long Term Lamivudine/Immunoglobulin Therapy.

PMID: 26300928 2015 Hepatitis monthly

Table: L180M

Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro.

PMID: 26220282 2015 BMC complementary and alternative medicine

Result: indicating that an additional L180M mutation in the P gene might confer LMV resistance.

4'-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.

PMID: 26122273 2015 Hepatology (Baltimore, Md.)

Abstract: Once-daily peroral administration of CAdA reduced HBVETV-RL180M/S202G/M204V viremia (P = 0.0005) in human-liver-chimeric/ HBVETV-RL180M/S202G/M204V-infected mice, whereas ETV completely failed to reduce HBVETV-RL180M/S202G/M204V viremia.

Abstract: Southern analysis using Huh-7 cells transfected with HBV-containing plasmids demonstrated that CAdA was potent against both wild-type (IC50= 7.2 nM) and ETV-resistant HBV (IC50= 69.6 nM for HBVETV-RL180M/S202G/M204V), whereas ETV failed to reduce HBVETV-RL180M/

Delayed Reduction of Hepatitis B Viral Load and Dynamics of Adefovir-Resistant Variants during Adefovir plus Entecavir Combination Rescue Therapy.

PMID: 26005376 2015 International journal of medical sciences

Result: During 27-36 months of combination treatment, no LAM-resistant variants (rtM204I/V with or without rtL180M) or ETV-resistant variants (rtT184, rtS202, or rtM250) were detected in the viral population.

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