Broad Range of Hepatitis B Virus (HBV) Patterns, Dual Circulation of Quasi-Subgenotype A3 and HBV/E and Heterogeneous HBV Mutations in HIV-Positive Patients in Gabon.
Method: Using the Mutation Reporter Tool software (http://hvdr.bioinf.wits.ac.za/mrt/), HBV resistance-associated mutations (RAMs) in the pol gene represented by V173L, L180M, A181V, A194T, S202G, M204V/I and N236T were assessed.
Result: Regarding RAMs, the mutation M204V/I, associated with the compensatory mutation L180M, was significantly more common in genotype HBV/A (9/19, 47.4%) than in genotype HBV/E (0/9, 0%) (Yate's corrected chi2, P = .04) (Fig 6, Table 2).
Table: L180M
Discussion: When considering HBV/A genotypes only, we observed a high (~50%) prevalence of PMID: 26825915
2016
Medicine
Discussion: At baseline, patient 1 harbored rtL180 M (2.09%), rtS202G (3.42%), and rtM204 V (3.45%) mutations, the frequencies of which rose to 19.12%, 18.33%, and 19.95%, respectively, after 1 year of treatment, but these changes did not cause virological breakthrough.
Discussion: In patient 5, when the resistant variants (rtL180 M, rtM204 V, rtS202G) began to rise to a high peak (84.60%, 79.56%, 76.88%) at 2 years, virological breakthrough occurred.
Discussion: In the present study, 7 patients harbored the rt
Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China.
PMID: 26876337
2016
The Brazilian journal of infectious diseases
Abstract: Mutations in HBV DNA polymerase were detected in 24 patients (8.9%) including rtM204I/V (n=6), rtN236T (n=5), rtM250V (n=2), rtL180M (n=2), rtT184G (n=1), rtM207I (n=1), rtS202I (n=1), rtM204V/I & rtL180M (n=5), and rtM204I &
Evolution of entecavir-resistant hepatitis B virus during entecavir and adefovir dipivoxil combination therapy.
PMID: 26889227
2016
Experimental and therapeutic medicine
Abstract: Clonal analysis further revealed that the rtS202G or rtT184F was in all cases co-localized with rtL180M and rtM204V in any single virus isolate clone.
Abstract: In patient A, the rtL180M, rtS202G and rtM204V mutant variants were detected using pyrosequencing prior to virological breakthrough.
Abstract: In patient B, the rtL180M, rtM204I and
[Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology].
Abstract: Each of the NAs had dominant drug-resistant mutational profiles, with rtM204I+rtL180M+-rtL80I (30.9%) for LAM, rtA181T/N (21.3%), rtS213T/N (21.3%) and rtV214A (21.3%) for ADV, rtl180M (48%) for ETV, rtM204I for LdT, and rtA194T for tenofovir disoproxil fumarate (TDF).
Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2.
PMID: 27006281
2016
Infection, genetics and evolution
Abstract: In addition, two patients harboring drug resistance mutations rtL80V+rtM204I and rtL180M+rtM204V were found.
Overt and occult hepatitis B virus infection among treatment-naive HIV-infected patients in Brazil.
Abstract: The detected resistance mutations were rtL180M (14/15 patients) and rtM204V/I (15/15).
Association between clinical features and YMDD mutations in patients with chronic hepatitis B following lamivudine therapy.
PMID: 27446286
2016
Experimental and therapeutic medicine
Abstract: The turn of secondary protein structure of P gene changed to beta sheet when a rtM204V mutation occurred, and no change of secondary protein structure was associated with the rtL180M mutation.
Abstract: Two patients with rtM204V + rtL180M belonged to genotype C and another patient with rtL180M alone belonged to genotype D.
Mutational analysis of reverse transcriptase and surface proteins of patients with partial virological response during mono and combination antiviral therapies in genotype D chronic hepatitis B.
Abstract: T54N, L80I/V, I91L/V, L180M, M204I/V, Q215P/S, and F221Y/S showed the highest number of mutations in all groups with different frequencies.
Result: L180M mutation (common to both LAM and
Discussion: It is interesting to note that mutants L180M and M204I that were detected during LAM and ADV breakthrough showed a high prevalence in the LAM-only group (25 and 50%, respectively), followed by a low frequency in the ADV-only group (9.9 and 23%, respectively), whereas they showed a very high frequency in group III in which the patients received ADV after LAM breakthrough (43.75 and 68.75%, respectively).
HBV mutation literature information.
PMID: 
2016
PloS one
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