Abstract: Replication-competent HBV constructs containing the naturally occurring rtQ215H, rtQ215P and rtQ215S mutations were generated, and compared to wild-type, LAM- (rtM204I, rtL180M/rtM204V) and ADV-resistant (rtN236T) clones.
Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B.
Abstract: The ETVr-related substitution (S202G), along with LVD-resistance-related substitutions (L180M and M204V), was detected by sequence analysis at week 124 in both case 1 and case 2.
[Identification of factors associated with YMDD mutation in patients with chronic hepatitis B receiving lamivudine treatment].
Abstract: rtM204V mutation in C gene was always accompanied by rtL180M mutation (100%).
Abstract: The point mutation of rtM204I and rtL180M appeared only in genotype B group.
Abstract: The rate of rtL180M/M204V mutation in genotype C group was significantly higher than that in genotype B group (77.8% to 25.0%), the same was true for the rtL180M/ M204I mutation (22.2% to 12.5%).
Abstract: There are four types of mutation:
[Entecavir resistance in entecavir naive lamivudine treated chronic hepatitis B patients].
Abstract: In these patients also rtL180M and rtQ215S mutations were detected as compensatory mutations and YVDD and YIDD variants were observed at the 204.
Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir.
Method: In one patient a HBV subpopulation with mutations rtM204V, rtL180M, and rtA194T could be detected.
Method: In vitro studies show that the rtA194T mutation alone resulted in a 7.6-fold decrease in susceptibility, but in conjunction with rtM204V and rtL180M led to a more than 10-fold decrease in susceptibility to TDF.
Method: The other patient presented with mutations in the HBV polymerase of rtM204V, rt
ViMRT
HBV mutation literature information.
PMID: 
2009
Journal of gastroenterology and hepatology
