Result: We also screened several mutations relevant to antiviral resistance, such as I169L, L180M, A181V, T184I, S202C, M204V/I, N236T and M250I in the RT region.
Predominance of Hepatitis B Virus Genotype A Among Treated HIV Infected Patients Experiencing High Hepatitis B Virus Drug Resistance in Nairobi, Kenya.
PMID: 28316253
2017
AIDS research and human retroviruses
Abstract: Five subjects had rtV173L, rtL180M, and rtM204V and one with rtL180M and rtM204V major mutations.
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Result: Direct sequencing of the PCR amplified RT domain of HBV/D from 16 LMV-failed patients demonstrated the presence of well-known LMV resistance mutations, rtM204V/I, rtL180M, rtS202G, rtL80I and rtA181T, either singly or in combinations.
Result: For those LMV- failed patients whose HBV carried either rtM204V + rtL180M or rtM204I + rt
Telbivudine versus entecavir in patients with undetectable hepatitis B virus DNA: a randomized trial.
Abstract: Seven patients (14.9%) exhibited genotypic resistance mutations (M204I +/- L180M) during the virologic breakthrough.
Result: Of these patients, genotypic resistance mutations to Telbivudine (M204I +/- L180M) were detected in seven during the virologic breakthrough.
Analysis of the prevalence of drug-resistant hepatitis B virus in patients with antiviral therapy failure in a Chinese tertiary referral liver centre (2010-2014).
PMID: 28017671
2017
Journal of global antimicrobial resistance
Abstract: M204I, N236T and L180M+M204V+V173L/S202G were the most common substitutions for l-nucleoside (3TC and LdT), ADV and ETV genotypic resistant phenotypes, respectively.
HIV therapy with unknown HBV status is responsible for higher rate of HBV genome variability in Ethiopia.
Abstract: Despite the finding that rtL180M and rtM204V/I were higher among ART-experienced individuals, the overall prevalence of DRMs (48.0% versus 36.4%) showed no significance difference among antiretroviral therapy (ART) status.
Abstract: Lamivudine selected DRMs, that is, rtL180M (29.3%) and rtM204V/I (29.3%) and rtV173L (15.5%) were more prevalent in HBV-HIV-coinfected individuals but absent in HBV-monoinfected individuals.
Abstract: RESULTS: In 34 out of 161 study subjects (21.1%) HBV drug resistance mutations (DRM
HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.
Discussion: Although there were differences in genotype, the dominant pattern of resistance among treatment-experienced patients with mutated strains, (rtM204V + rtL180M), was similar between the European multi-center study (29%) and the present study in Ghana (47.6%).
Discussion: In our study, twenty (95.2%) of the 21 patients had at least one mutation that may confer clinical resistance to both telbivudine (rtM204V/I) and 3TC (rt180M + rtM204V/I, rtV173L + rtL180M + rt PMID: 28139541
2016
The Indian journal of medical research
Abstract: Mutations: rtM204V (39.3%), M204V+L180M (10.7%) while rtA181V (8.1%) and
Result: Mutation in the YMDD, M204V (methionine to valine) in 39.3 per cent and along with L180M (leucine to methionine) in 10.7 per cent was detected in the conserved regions C and B of reverse transcriptase (rt) domain of HBV polymerase, respectively, after 24 months of LAM therapy.
Discussion: In addition, there was another compensatory mutation i.e., L180M + M204V.
Serologic and genotypic characterization of hepatitis B virus in HIV-1 infected patients from South West and Littoral Regions of Cameroon.
Result: Mutations rtV173L, rtL180M, rtM204V conferring resistance to lamivudine and other L-nucleoside analogues were identified in six patients while one patient had the rtL180M + rtM204V + rtT184S mutations associated with resistance to both L-nucleoside analogues and entecavir.
Table: L180M
Discussion: The mutation rtL180M found together with the rtM204V mutation in these patients is
Monitoring of genotypic resistance profile in chronic hepatitis B patients receiving nucleos(t)ide analogues in Huzhou, China.
PMID: 27694733
2016
Journal of infection in developing countries
Abstract: Among patients who harbored rtM204 combination mutations, rtM204I and rtM204V were significantly associated with rtL80I/V and rtL180M, respectively.
HBV mutation literature information.
PMID: 
2017
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