literature

HBV mutation literature information.

Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.

PMID: 29408943 2018 PloS one

Method: In particular, the HBV-HIV co-infected group was characterized by the YMDD RT associated 3TC/ETV drug resistance gene mutations (rtM204V/I) which appeared as multiple combinations with other mutant variants, such as rtV173L and rtL180M.

Discussion: Moreover, with a proportional HBeAg positive and negative status, 29.3% of HIV co-infected patients included in the current study were reported to have 3TC/ETV resistance due to rtM204V/I+rt

2'-Fluoro-6'-methylene carbocyclic adenosine and its phosphoramidate prodrug: A novel anti-HBV agent, active against drug-resistant HBV mutants.

PMID: 29406612 2018 Medicinal research reviews

Abstract: In vitro, these molecules have demonstrated significant activity against LMV/entecavir (ETV) triple mutants (L180M + S202G + M204V).

Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.

PMID: 29315352 2018 PloS one

Method: As previously described, we used the Mutation Reporter Tool (MRT) software (http://hvdr.bioinf.wits.ac.za/mrt/) to look for HBV resistance-associated mutations (RAMs) in the Polymerase catalytic domain represented by major RAMs (A181T/V/S, A194T, M204V/I/S and N236T) and compensatory RAMs (I169T

Result: The analysis of HBV strains for the S/Pol gene by the MRT online software showed that of the major RAMs, M204V/I was the most frequent (4/10, 40%), followed by its compensatory RAMs; L180M (3/10, 30%) and V173L (2/10, 20%).

Table: L180M

Evolution of drug-resistant mutations in HBV genomes in patients with treatment failure during the past seven years (2010-2016).

PMID: 29119303 2018 Virus genes

Abstract: For single-base mutations, rtL180M and rtA181V increased gradually during the past seven years, while rtM204I/V and rtN236T decreased after 2015.

Abstract: Frequencies of rtL180M and rtA181T/V increased gradually in the past seven years, to which we should pay more attention.

Abstract: Moreover, single-base mutation rtA181V and multi-base mutations (rtL180M + M204I

The burden of hepatitis B virus (HBV) infection, genotypes and drug resistance mutations in human immunodeficiency virus-positive patients in Northwest Ethiopia.

PMID: 29281718 2017 PloS one

Abstract: All HIV/HBV positive cases were on ART with anti-HBV activity (i.e., 3TC) and 3TC associated HBV DRMs (i.e., rtV173L, rtL180M, and rtM204V) were detected in 7/13 (53.8%) subjects.

Result: rtV173L, rtL180M, and/or rt Discussion: We found that more than half of these patients, for whom sequence data were available, had 3TC selected DRMs (rtV173L, rtL180M, and rtM204V).

HBV Drug Resistance Substitutions Existed before the Clinical Approval of Nucleos(t)ide Analogues: A Bioinformatic Analysis by GenBank Data Mining.

PMID: 28749433 2017 Viruses

Introduction: According to several clinical practice guidelines and authoritative reviews, NUCr substitutions can be

Discussion: Furthermore, in vitro studies showed that substitutions rtS202R and rtM250K would severely impair the replication capability of HBV variants with LAM resistance substitutions (rtL180M + rtM204V), while substitution rtS202T played only a minor role in ETV resistance.

Discussion: It has been related to ETV resistance in the presence of the rtM204V + rtL180M backbone.

Genotyping of HBV and tracking of resistance mutations in treatment-naive patients with chronic hepatitis B.

PMID: 28740410 2017 Infection and drug resistance

Discussion: One of the resistance mutations found in the Northeastern Region was rtA194T, which can be associated with resistance to TDF, which has shown in vitro reduced susceptibility to TDF when combined with the resistance mutations to LAM M204V and L180M.

Discussion: The other two mutations are associated with resistance to LAM rtL180M + rtM204V and rtS202I.

Discussion: The resistance mutations rtL180M + rtM204V and rtS202I

Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India.

PMID: 28591184 2017 PloS one

Result: Despite the patient population being ART-naive, one OBI sample (O-EICIS.9; belonging to HBV/A1) of 17 (5.9%) harbored the rtL180M+rtM204V lamivudine resistant mutations.

Table: L180M

Discussion: Furthermore, 3TC resistance mutations (rtL180M + rtM204V) were also observed in one of the OBI patients, despite the population being treatment-naive.

Mutations associated with drug resistance and prevalence of vaccine escape mutations in patients with chronic hepatitis B infection.

PMID: 28500726 2017 Journal of medical virology

Abstract: Six patients (7%) exhibited resistance mutations to LAM, ETV, and TDF: two with patterns L180M + M204V and four with other different patterns: L80I + L180M + M204I; L80V + L180M + M204V; M204I; A194T.

Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.

PMID: 28392234 2017 Journal of hepatology

3Introduction: The molecular explanation is that ETV resistance usually requires the LAM-resistant ""YMDD mutation(s)"" (rtM204V/I +-L180M) plus an additional ETV 'signature' substitution in the B domain (rtI169T or rtS184G), C

Result: Other mutations, especially those related to LAM or ETV resistance (rtL180M and rtM204V/I) and classical immune escape (sG145R and/or P120T) variants were noted at no or very low frequencies (Table 1), despite ETV treatment.

Browser Board

Co-occurred Entities

Filtrator