literature

HBV mutation literature information.

Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy.

PMID: 16871563 2006 Hepatology (Baltimore, Md.)

Abstract: Lamivudine-associated mutations (rtV173L, rtL180M, rtM204V/I) could be detected in 6 patients at baseline of TDF, but this obviously did not influence the response.

Detection of YMDD mutation using mutant-specific primers in chronic hepatitis B patients before and after lamivudine treatment.

PMID: 16981258 2006 World journal of gastroenterology

Abstract: Pair primers specific to rtL180M and rtM204V were selected for YVDD detection.

Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient.

PMID: 17030194 2006 Gastroenterology

Abstract: As viral load rose again, a single viral population was progressively selected, harboring the rtV173L+L180M+A181V+N236T and sP120S mutations.

Abstract: Interestingly, among these mutants emerged a population harboring only the rtL180M+A181V mutations, conferring lamivudine-resistance in vitro.

YMDD motif variants in inactive hepatitis B carriers detected by Inno-Lipa HBV DR assay.

PMID: 17074014 2006 Journal of gastroenterology and hepatology

Abstract: In two patients, only YIDD and/or YVDD variants plus L180M were detected without the presence of wild YMDD motif.

Abstract: Of the 13 patients, 10 (76.9%) also had accompanying L180M mutation.

Activity of adefovir dipivoxil against all patterns of lamivudine-resistant hepatitis B viruses in patients.

PMID: 15655050 2005 Journal of viral hepatitis

Abstract: Four major patterns of lamivudine-resistant HBV were identified: rtL180M + rtM204V (60%), rtV173L + rtL180M + rtM204V (19%), rtM204I (9%) and rtL180M + rtM204I (9%).

Abstract: In addition to the rtM204V/I and the rtL180M mutations, the mutation

Sustained HBs seroconversion during lamivudine and adefovir dipivoxil combination therapy for lamivudine failure.

PMID: 15664258 2005 Journal of hepatology

Abstract: Lamivudine resistance was associated with the selection of a L180M+M204V polymerase mutant.

Long-term follow-up of chronic hepatitis B after the emergence of mutations in the hepatitis B virus polymerase region.

PMID: 15720530 2005 Journal of viral hepatitis

Abstract: In most cases, wild-type HBV was mutated with the substitution of only rtM204I at first, and rtL180M/M204I mutations and then rtL180M/M204V mutations subsequently appeared.

Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir.

PMID: 15915463 2005 Hepatology (Baltimore, Md.)

Abstrac

Abstract: Considering the use of de novo or add-on 3TC+ADV bitherapy, we investigated the possibility of the emergence of an HBV strain harboring polymerase mutations conferring resistance to both 3TC (rtL180M+M204V) and ADV (rtN236T).

Abstract: In conclusion, the combination of rtL180M+M204V and rtN236T mutations impairs HBV replication and confers resistance to both 3TC and ADV in vitro.

Changes in different regions of hepatitis B virus gene in hepatitis B 'e' antigen-negative patients with chronic hepatitis B: the effect of long-term lamivudine therapy.

PMID: 15932365 2005 Alimentary pharmacology & therapeutics

Abstract: YMDD mutations were observed in nine cases and both, L180M and M204V/I mutations were simultaneously detected in six cases.

Character of HBV (hepatitis B virus) polymerase gene rtM204V/I and rtL180M mutation in patients with lamivudine resistance.

PMID: 15973769 2005 Journal of Zhejiang University. Science. B

Abstract: Among them, 45 patients had rtL180M/M204V mutation (41.28%), 28 patients had rtL180M/M204I mutation (25.70%) and 36 patients had rtM204I mutation (33.02%).

Abstract: There were 6 patients with rtL180M mutation in 32 lamivudine resistance patients.

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