Discussion: In our study, despite the frequent association of the primary resistance mutations M204V/I with the compensatory L180M, V173L, and L80V/I mutations, lamivudine-resistant HBV strains tend to be associated with lower viral loads compared to wild-type strains; further characterization of the viral strains, using Next-Generation Sequencing (NGS), might reveal the presence of other mutations that alter viral replication.
Discussion: The most frequently LAM-associated mutations detected in this study were M204V and V173L, commonly reported worldwide across all genotypes, with a similar distribution in HBV genotype A and D infections, as dual (M204V + L180M) and triple mutations (
Hepatitis B virus genetic multiplicity and the associated HBV lamivudine resistance mutations in HBV/HIV co-infection in Western Kenya: A review article.
PMID: 34954390
2022
Infection, genetics and evolution
Abstract: HBV polymerase rtV173L, rtL180M, and rtM204V major substitutional mutations were identified.
Dried blood spot sampling for hepatitis B virus quantification, sequencing and mutation detection.
Abstract: An HIV-coinfected patient presented the rtM204V/I-rtL180M double resistance mutation in serum and DBS.
Result: One patient had the double resistance polymerase mutation rtM204V/I-rtL180M, in both serum and DBS.
Table: L180M
Discussion: Regarding resistance mutations, the double rtM204V/I-rtL180M mutation in polymerase gene (to lamivudine, telbivudine and entecavir:partial) was observed in both serum and DBS samples from an
Identification and Characterization of Besifovir-Resistant Hepatitis B Virus Isolated from a Chronic Hepatitis B Patient.
Discussion: But it may become a dominant species when combined with rtL180M mutation in vivo because of enhanced replication capability.
Discussion: On the other hand, rtL180M itself seems to be resistant to BFV as shown in Figure 3c, but there was stronger resistance to BFV in MV clone containing Discussion: The rtL180M and rtM204V mutations may have been occurred gradually while taking ETV as the first line anti-HBV agent.
Discussion: The mechanism of BSV resistance in patient who was positive for rtL180M and rtM204V mutations is not clear.
Reactivation of Occult Hepatitis B Virus Infection During Long-Term Entecavir Antiviral Therapy.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Introduction: In contrast, the HBV variant with three mutations in the polymerase gene (rtV173L + rtL180M + rtM204V), also generating the G145R mutation in S-HBsAg due to overlapping reading frames, was stable.
Entecavir resistance in a patient with treatment-naive HBV: A case report.
PMID: 33903819
2021
Molecular and clinical oncology
Introduction: In fact, resistance to ETV appears to occur through a two-hit mechanism with primary LVD resistance (LVDr) substitutions (M204V/I with/without rtL180M) followed by amino acid substitutions at the rtI169, rtT184, rtS202 or rtM250 sites.
Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.
Result: L180M and M204I/V were both present in all genotypes and continents that we analysed (Figure 1B, C).
Result: However, four sequences (KF214668, KF214671, KF214673 and KF214676) with RAM I269L and one sequence (KF214659) with VEM S/T143M were sampled from Asia in 1963, and one sequence (HQ700441) with RAM L180M was sampled from Oceania in 1984, demonstrating that relevant mutations can arise without exposure to treatment or vaccination.
Result: RAMs L80I/M/V, V173L, L180M, A181T/V and T184X are common to 3TC, ETV and/or TFV.
Result: Some sequences containing both
The Occurrence of rtA194T Mutant After Long-Term Lamivudine Monotherapy Remains Sensitive to Tenofovir Disoproxil Fumarate: A Case Report.
Abstract: We present here a 62-year-old CHB patient who occurred rtL180M, rtM204V and rtA194T mutants after lamivudine (LAM) monotherapy for 9 years.
Introduction: Here, we report a case of a CHB patient who developed rtM204V, rtL180M and rtA194T mutations in association with viral breakthrough on LAM monotherapy and was rescued by TDF.
Introduction: Meanwhile, phenotypic analyses revealed that constructs harboring rt
Prevalence and characteristics of hepatitis B and D virus infections among HIV-positive individuals in Southwestern Nigeria.
Abstract: HBV DRMs V173L, L180M, S202I and M204V/I, which are associated with lamivudine resistance, were detected in 32.2% (n = 10/31) of the HBV DNA-positive samples.
Discussion: Amino acid (aa) substitutions found in this study include rtL180M, rtV173L, rtM204V/I among individuals on ART however, in one drug-naive individual, aa substitutions L180M, M204V and S202I have also been detected.
Discussion: Here, we found a high prevalence of resistance mutations to nucleoside analogues and predominantly mutations usua
HBV mutation literature information.
PMID: 
2022
Medicina (Kaunas, Lithuania)
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