Replicative competence of the T131I, K141E, and G145R surface variants of hepatitis B Virus.
PMID: 17763322
2007
The Journal of infectious diseases
Abstract: Point mutations leading to sT131I, sK141E, and sG145R amino-acid substitutions were engineered by site-directed mutagenesis into an infectious plasmid clone of the virus.
Abstract: The sT131I and sG145R variants replicated with efficiency equal to that of the wild type, whereas the sK141E variant was replication impaired.
"Molecular analysis of hepatitis B virus ""a"" determinant in asymptomatic and symptomatic Mexican carriers."
Discussion: The most relevant mutations seem to be the substitutions of amino acid G145R, K141E and T131I and insertion of 3 amino acids between residues 123 and 124, since they markedly affect the antigenic structure of HBsAg.
Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers.
1Abstract: These changes involved 11 positions inside and 5 outside of the historical first and second loops of the ""a"" determinant, and included the following: Q101K, T115A, K122N, T123A, T126N, Q129N, G130R, T131I, M133T, F134L, C138Y, K141E, P142S, G145R, N146S, and C147F/R."
"Effect of variation in the common ""a"" determinant on the antigenicity of hepatitis B surface antigen."
Abstract: The results suggest that amino acid substitution of T131I, K141E and G145R and insertion of 3 amino acids between residues 123 and 124 markedly affect the antigenic structure of HBsAg.
A novel hepatitis B virus variant in the sera of immunized children.
PMID: 8113769
1994
The Journal of general virology
Abstract: A unique nucleotide change from adenosine to guanosine at nucleotide 421 was found, resulting in an amino acid substitution at residue 141 from lysine to glutamic acid.
HBV mutation literature information.
PMID: 
2007
The Journal of infectious diseases
Browser Board
Co-occurred Entities
Filtrator
ViMRT