Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene.
PMID: 19439550
2009
The Journal of general virology
Abstract: Due to a compact viral genome organization, BCP1 and BCP2 mutations result in amino acids changes in the overlapping X gene: K130M/V131I and F132Y, respectively.
Hepatitis B virus genotypes/subgenotypes in voluntary blood donors in Makassar, South Sulawesi, Indonesia.
Discussion: Another study also reported that K130M and V131I substitutions, which are corresponding to double mutation in BCP, from Indian inactive carrier were generally high (36.0%).
Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma.
PMID: 18695135
2008
Journal of the National Cancer Institute
Discussion: Mutations in the BCP region, which overlaps the coding sequence for the X antigen of HBV, may result in amino acid changes K130M and V131I in the X antigen.
Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection.
Abstract: All five mutation types (V5M/L, P38S, H94Y, I127T/N, and K130M and V131I) affecting the six codons were found to be related significantly to clinical severity.
Abstract: Among these, two mutation types (V5M/L and K130M and V131I) were observed more frequently in HBeAg negative patients than in HBeAg positive patients.
HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers.
Introduction: A double point mutation with a transversion nucleotide from adenine to thymine at nucleotide 1762, K130M with a transition from adenine to guanine at position 1764 V131I (T-A mutations), has been found more frequently in patients with hepatic tumors than in asymptomatic chronic patients from China and Africa.
Table: K130M
"Biological impacts of ""hot-spot"" mutations of hepatitis B virus X proteins are genotype B and C differentiated."
PMID: 16094714
2005
World journal of gastroenterology
1Abstract: METHODS: Five types of ""hot-spot"" mutations of genotype B or C HBV X genes, which sequentially lead to the amino acid substitutions of HBx as I127T, F132Y, K130M+V131I, I127T+K130M+V131I, or K130M+V131I+F132Y, respectively, were generated by means of site-directed mutagenesis."
Abstract: RESULTS: As compared to standard genotype B HBx, mutants of I127T and I127T+K130M+V131I showed high
Comparison of full length sequences of hepatitis B virus isolates in hepatocellular carcinoma patients and asymptomatic carriers of Korea.
Abstract: Third, mutations (I127T/N, K130M, and V131I) at three codons in the carboxy functional region of X protein were observed in isolates from all three HCC patients.
Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure.
Abstract: Subsequent to the instigation of antiviral therapy, the dominant drug resistant HBV which caused virological breakthrough and was associated with hepatic failure displayed a series of unique mutations particularly in the BCP (A1762T and G1764A) and in the polymerase (rtL180M, rtM204V, rtA222T and rtL336V), core (cP5T, cS26A,
Hepatitis B virus X gene variability in French-born patients with chronic hepatitis and hepatocellular carcinoma.
1Abstract: The changes K130M and V131I, considered as ""hot spot mutations,"" were found in strains of HCC patients carrying an ayw subtype of the HBV genome but not in the ones of chronically infected patients."
Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation.
Abstract: In addition, this double mutation also resides in the X protein coding sequence, converting codon 130 from Lys to Met and codon 131 from Val to Ile.
HBV mutation literature information.
PMID: 
2009
The Journal of general virology
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