Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.
Abstract: All occult HBV infection-associated Y100C and common diagnostic and vaccine-escape-associated P120T, G145R, K122R, M133L, M133T, Q129H, G130N, and T126S mutations were reliably detected by the assay, which consistently detected the presence of HBsAg in all 179 samples including samples with 11 novel mutations.
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Result: To note, 75.00% (9/12) of their sequences harbor one or two of our newly identified SHBs mutations (sL21R, sT47K, sL95W, sK122R, sI126T, sG145R and sW182*) (Supplementary Table 2).
Result: revealed previously identified immune escape mutations within the 'a' determinant region (sS117T, sK122R, <
Molecular epidemiology of hepatitis B virus isolated from Bangladesh.
Result: On the other hand, there were several amino acid mutations like K122R (amino acid Lysine at 122 position of S protein instead of Arginine), T131S and I208T in genotype C.
Spontaneous reactivation of hepatitis B virus replication in an HIV coinfected patient with isolated anti-Hepatitis B core antibodies.
Abstract: Multiple mutations occurred in the S gene during the flare-up of HBV as shown by sequencing, including I103T, K122R, M133I, F134V, D144E, V164E and L175S.
Discussion: Most of the other aa substitution in the HBsAg found during the flare-up phase described here have been reported before and in combination with the K122R mutation, possibly causing HBV escape from anti-HBs.
Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro.
Result: The G145A, M103I+G145A, K122R+G145A, and M103I+K122R+G145A vectors continued to have higher intracellular HBsAg levels at all time points in Huh7 cells, when above the detection limit.
Discussion: The M103I or K122R mutations alone did not significantly affect
Discussion: Thus, we examined the effects of three previously identified O-HBV mutations in the S region - M103I, K122R, and G145A - on HBsAg expression.
Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China.
Abstract: Six amino acid mutations were located in the 'a' determinant, including P120T, K122R, M133T, F134L, D144A and G145A.
Abstract: The mutants K122R, F134L and G145A in our patient have not been tested for their sensitivity to Architect and Murex assays by the previous investigators and might represent the escape mutants to these assays.
HBV mutation literature information.
PMID: 
2018
Journal of clinical virology
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