Abstract: CONCLUSIONS: The study clarified the clinical prevalence of OBI, verified the influence of immune escape-associated mutations, and identified the role of the sK122R mutation in multiple OBI patients.
Abstract: Specifically, the prevalence rates of sT118 K, sK122R, and sV168A were increased in OBI patients.
Abstract: Strains with sK122R mutants (sK122R, s
In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Introduction: This study attempted to identify mutations (K122R, N131T, F134Y, P142L, and T126N) in S gene, N-glycosylation sites (4, 112, 166, and 309), compare Ahvaz samples with isolates from other regions of the world using the phylogenetic tree, and investigate the tertiary structures of isolates.
Result: The results of our amino acid sequences of the preS/S gene compared to consensus genes showed several mutations at position L109R, T113S, K122R, T126N, N131T, F134Y,
Novel hepatitis B virus surface antigen mutations associated with occult genotype B hepatitis B virus infection affect HBsAg detection.
Abstract: Ten occult infection-related mutations (E2G, Q101R, K122R, M133T, D144E, G145R, V168A, S174N, L175S and I226S) were significantly more frequent in the occult infection group (P < .05).
Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.
PMID: 31682960
2020
International journal of infectious diseases
Discussion: other mutations like K122R and F134I detected in the 'a' determinant support the idea of IEMs associated with strains harboring the sY100C as discussed in the present study.
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Discussion: In Turkey, the most frequent mutations observed were T143M and K122R, whereas in Egypt 14.8% presented with mutations in the MHR, and eight different mutations were discovered: R122K, S143L, L109P, S114P, S117N, P127S, P127T and Y134F.
Hepatitis B Virus (HBV) Infection and Re-activation During Nucleos(t)ide Reverse Transcriptase Inhibitor-Sparing Antiretroviral Therapy in a High-HBV Endemicity Setting.
PMID: 30377627
2018
Open forum infectious diseases
8Discussion: Y100C and K122R have been previously recognized in the context of HBsAg-negative HBV infection (""occult hepatitis B""); Y100C has also been previously described in a patient with co-circulating HBsAg and anti-HBs."
Abstract: In one case of reactivation, anti-HBs increased from 14 to >1000 IU/L; sequencing showed HBV genotype A3 and 3 escape mutations in surface (Y100C, K122R, Y161FY).
HBV mutation literature information.
PMID: 
2022
PloS one
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