Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
PMID: 27727182
2016
International journal of molecular sciences
Discussion: A2159G and A2189Y mutations are missense mutations resulting in an amino acid change of HBcAg codons 87 (S87G) and 97 (I97L/F), respectively.
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
8Discussion: Interestingly, the most frequently observed naturally occurring core protein mutation found in CHB and also in HCC patients I97L or F97L which is associated with ""immature virion secretion"" was completely absent in Indian patients with HBV-genotype D while among the ""low secretion core variants"" such as P5T/A/S, a new variant P5R was noted with high frequency in HBV-genotype D related HCC in previous Indian study."
Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
Abstract: Incidences of point mutation T53C (preS1F53L), G1613A (polR841K), G1775A and A1762T + G1764A in the basal core promoter region, G1896A and G1899A in precore region and A2189C (coreI97L) in core region increased along with acute hepatitis B, chronic hepatitis B, and acute-on-chronic liv
Variability of the preC/C region of hepatitis B virus genotype A from a South African cohort predominantly infected with HIV.
Abstract: Other mutations (e.g., P5H/L and I97L) associated with severe liver disease were also noticed, some of which were located in the major histocompatibility restricted sites.
Discussion: P5H/L and I97L amino acid mutations in genotype C of HBV (all of which were noticed in this study) were recently found to be associated with HCC, and I97L w
Discussion: I97L and A131P amino acid mutations have been associated with failure to express HBeAg; both these mutations have also been found in this study in patients who did not express HBeAg (3812, 3464, 3734, and 3319).
Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.
Abstract: Six (preC-W28*, C-P5H/L/T, C-E83D, C-I97F/L, C-L100I and C-Q182K/*) and seven types (preC-W28*, preC-G29D, C-D32N/H, C-E43K, C-P50A/H/Y, C- PMID: 21325784
2012
Intervirology
Abstract: The most frequently occurring mutations in rank were codon P130T (38.8%), I97L (37.8%) and S87G (23.5%).
Hepatitis B virus core protein with hot-spot mutations inhibit MxA gene transcription but has no effect on inhibition of virus replication by interferon alpha.
Abstract: However, in Huh7 cells stably expressing WT or the mutated HBc proteins (L60V, S87G or I97L), IFN-alpha could inhibit the extra- and intracellular HBV DNA level and HBsAg secretion to a similar level compared to that in cells transfected with control plasmids.
Abstract: In conclusion, HBc protein with I97L mutation may play an special role in suppressing the transcription of MxA gene.
Abstract: In this study, we investigated whether HBc protein mutations at hot spots (L60V, S87G and I97L) could still inhibit MxA transcription and the potential significance of this inhibition in virus replication in
Molecular characteristics and functional analysis of full-length hepatitis B virus quasispecies from a patient with chronic hepatitis B virus infection.
Abstract: In the core protein, cI3L, cL60M, and cI97L were detected in 8 of 10 clones and cP130T was detected in all 10 clones.
Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.
3Introduction: On the other hand, a naturally occurring I97L mutation in the core protein caused an ""immature secretion phenotype"" of predominantly single stranded DNA."
Discussion: In contrast, a P5T mutation impairs virion secretion when present alone and restores wild-type secretion phenotype when combined with the I97L mutation.
HBV mutation literature information.
PMID: 
2016
International journal of molecular sciences
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