literature

HBV mutation literature information.

Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.

PMID: 35415256 2022 Clinical and experimental hepatology

Introduction: In a study conducted in the Korean population, the five HBcAg mutations P5H/L/T, E83D, I97F/L, L100I, and Q182K/Stop were significantly more frequent in subjects with chronic hepatitis and cirrhosis.

rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.

PMID: 33803998 2021 Microorganisms

Result: Indeed, a previous study reported that C-I97F/L (A2189T/C or C2191T mutation) was the preC/C type found the most frequently in HCC patients in Korean chronic patients infected with genotype C2.

Result: The C-I97F/L in the C region, of which the frequency was significantly higher in rt269I strains than in rt269L strains (q = 0.047), is well known as the most frequently encountered HBcAg mutation, as mentioned in several studies leading to an immature secretion phenotype due to defective nucl

The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.

PMID: 30406036 2018 Frontiers in cellular and infection microbiology

Introduction: Furthermore, five HBcAg mutations identified in a Korean population, P5H/L/T, E83D, I97F/L, L100I, and Q182K/Stop, were shown to be significantly enriched in HCC patients compared with patients at earlier disease stages, including those with cirrhosis and chronic hepatitis (Kim et al.,).

Table: I97F

Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.

PMID: 27727182 2016 International journal of molecular sciences

Discussion: A2159G and A2189Y mutations are missense mutations resulting in an amino acid change of HBcAg codons 87 (S87G) and 97 (I97L/F), respectively.

Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.

PMID: 24587360 2014 PloS one

Discussion: A recent study showed that HBV/C related P5H, I97F/L and L100I mutations were significantly associated with HCC.

Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.

PMID: 23071796 2012 PloS one

Result: Notably, the following 4 of 5 HCC-related C mutations, C-P5H/L/T, C-E83D, C-I97F/L and C-L100I, were located at M2RR (one at aa 1-20 and three at aa 81-105.

Discussion: C-I97F/L, most frequently found in HCC

Discussion: Of the five mutations in the C region positively related to HCC found in this study, the following three types, C-P5H/L/T, C-E83D, and C-I97F/L were introduced by other studies.

[Detection and analysis of gene polymorphism in hepatitis B virus C region].

PMID: 22097597 2011 Zhonghua shi yan he lin chuang bing du xue za zhi

Abstract: Four hepatitis B patients had mutation nt1896 g-->a, and another 4 patients had 2 mutations, namely, S87G and I97F (or 197L) in HBcAg CTL recognition episome.

Analysis of the core gene of hepatitis B virus in Korean patients.

PMID: 17498248 2007 Liver international

Abstract: The frequency of the codon I97F substitutions was the highest in group III.

Browser Board

Co-occurred Entities

Filtrator