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 HBV mutation literature information.


  The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
 PMID: 30406036       2018       Frontiers in cellular and infection microbiology
Table: I27V


  Presence of valine at position 27 of the hepatitis B virus core gene is associated with severe liver inflammation in Chinese patients.
 PMID: 21181915       2011       Journal of medical virology
Abstract: In summary, this is the first data showing an association between a specific amino acid mutation (I27V) and severe liver inflammation in patients with chronic hepatitis B.
Abstract: The frequency of the I27V mutation in the HBV core gene, which produces a core 18-27 peptide capable of binding HLA-A*02, was compared in Chinese patients with severe liver inflammation (n = 77, including 39 with acute-on-chronic liver failure), moderate liver inflammation (n = 44) and inactive disease (n = 45).



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