Hepatitis B in the Northwestern region of Sao Paulo State: genotypes and resistance mutations.
PMID: 34755817
2021
Revista do Instituto de Medicina Tropical de Sao Paulo
Result: One sample (1.1%) presented a compensatory mutation (rtV/F/L/M207I), which typically appears after other primary variants of resistance to LAM; and 26.7% (24/90) of the samples showed potential resistance mutations for ADF (rtV214A, rtL217R, rtP237H, rtN238T, rtQ215S, and rtI233V).
High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy.
PMID: 33986897
2021
The Canadian journal of infectious diseases & medical microbiology
Discussion: Furthermore, some pregnant women had multibase mutations combined with rtM204I/V at baseline, including rtM204I + rtA181 T/V, rtM204I/V + rtL80I/V, rtM204I/V + rtN236 T, and rtM204I/V + rtI233 V, which may affect their sensitivity to LAM, TBV, ADV, and TDF.
Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.
PMID: 33562603
2021
International journal of molecular sciences
Discussion: In ADV-treated patients, the reduced replication capacity of rtN236T mutant, which is well-known for ADV resistance, was restored by a compensatory mutation rtI233V.
Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.
Result: Putative resistance mutations were observed at 8 AA sites among the panel of treatment-naive patients; they were rtV191I, rtS213T, rtV214A, rtE218D, rtL229V, rtI233V, rtN238S, rtS/C256G.
Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.
Discussion: Multiple-point mt are found to be rare, including rtV207M + rtV207I; rtV207M + rtS213T; rtV207M + rtL229V; rtV207M + rtI233V; rtN238A + rtS256G; rtL180M + rt
Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.
PMID: 31189581
2019
Journal of clinical microbiology
Result: Considering that the low sensitivity of Sanger sequencing limited the detection of NAr mutations with a low rate (<20%), 4 classical drug resistance mutations (S202C/G/I, M204I/V/S, N236T, and M250I/L/V) and 12 putative NAr mutations (V207I, S213T, V214A, Q215P/S, L217R, E218D, L229G/V/W/F, I233V, P237H, N/H238D/S/T, Y245H
Table: I233V
Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot.
PMID: 31880889
2019
Polish journal of microbiology
Discussion: When analyzed in greater details, rtM204I, rtI233V, rtL80I, and rtL180M mutations were not detected before, and these mutations, particularly rtL80I and rtL180M, restore the activity of viral polymerase to near wild type levels, which helps to promote the replication of mutants.
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Result: In respect to PC mutations, co-distribution of the overall PC mutations and ADV resistance gene variants (rtQ215H and rtI233V) were common during HIV co-infection.
Discussion: Other than YMDD RT motif resistance gene mutations, the observation of co-prevalence of PC mutations and ADV resistance mutants (rtI233V, rtQ215S/Q and rtV214A) in particular in the
ViMRT
HBV mutation literature information.
PMID: 
2022
Frontiers in microbiology
