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 HBV mutation literature information.


  Hepatitis B genotype G and high frequency of lamivudine-resistance mutations among human immunodeficiency virus/hepatitis B virus co-infected patients in Brazil.
 PMID: 20944991       2010       Memorias do Instituto Oswaldo Cruz
Abstract: In 10 patients with viremia, LAM-resistance mutations in the polymerase gene (rtL180M + rtM204V and rtV173L + rtL180M + rtM204V) were found, accompanied by changes in the envelope gene (sI195M, sW196L and sI195M/sE164D).


  Effect of HIV co-infection on mutation patterns of HBV in patients with lamivudine-resistant chronic hepatitis B.
 PMID: 19475624       2009       Journal of medical virology
Abstract: All patients with the triple mutational pattern showed sE164D + sI195M changes in the envelope gene.


  Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model.
 PMID: 19274751       2009       Hepatology (Baltimore, Md.)
Abstract: The polymerase gene mutant contained a combination of three mutations (rtV173L, rtL180M, rtM204V), two of which resulted in changes to the overlapping viral envelope of the hepatitis B surface antigen (sE164D, sI195M).


  Occult hepatitis B virus infection in HIV-infected patients: Evaluation of biochemical, virological and molecular parameters.
 PMID: 18624719       2008       Hepatology research
Abstract: In the second patient, E164D and I195M substitutions in HBsAg, associated with lamivudine-resistance mutations in the polymerase were identified.


  Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil.
 PMID: 18211717       2008       BMC microbiology
Discussion: The triple mutation rtV173L/rtL180M/rtM204V/I results in concomitant amino acid substitutions E164D and I195M in the small S protein.


  "Molecular analysis of hepatitis B virus ""a"" determinant in asymptomatic and symptomatic Mexican carriers."
 PMID: 17217533       2007       Virology journal
Discussion: Thus for mutations associated with LMV resistance, the rtM204V change is associated with a I195M change in the S gene (sI195M), while the rtM204I change is associated with three possible changes in the S gene, sW196S, sW196L, or a stop codon.


  Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India.
 PMID: 16428891       2006       Intervirology
Abstract: Following lamivudine therapy, 14 of 57 (24.5%) patients developed 16 types of S-gene mutations (sP120S, sA128V, sS143L, sW182St., sT189I, sV190A, sS193L, sI195M, sW196L, sW196St., sS207R,


  [HBs antigen mutants: prevalence, clinical and diagnostic implications].
 PMID: 16099111       2005       Pathologie-biologie
Abstract: Changes I195 M and W196L, reflecting lamivudine resistance are present among 18 patients (33%).


  Failure of the lamivudine-resistant rtM204I hepatitis B virus mutants to efficiently support hepatitis delta virus secretion.
 PMID: 15858045       2005       Journal of virology
Abstract: The major HBV lamivudine (LMV)-resistant mutations in the polymerase gene within the reverse transcriptase (rt) region at rtM204V or rtM204I are associated with changes in the overlapping envelope gene products, in particular, the gene encoding small envelope protein (s) at sI195M or sW196L/S/Stop.
Abstract: We have demonstrated that the LMV resistance mutations corresponding to sW196L/S inhibited secretion of


  Hepatitis B virus variants in an HIV-HBV co-infected patient at different periods of antiretroviral treatment with and without lamivudine.
 PMID: 15339340       2004       BMC infectious diseases
Discussion: The triple mutation V519L, L526M, M550V causes the concomitant amino acid substitutions E164D and I195M in the small S protein.



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