Result: The results indicated that rtL180M and/or rtM204V/I and/or rtQ267H had no influence on HBsAg and HBeAg expression comparing to that of WT HBV, in spite of the fact that rtM204V and rtM204I led to sI195M and sW196S in S ORF, due to overlapping between S and P gene.
Decreased antigenicity profiles of immune-escaped and drug-resistant hepatitis B surface antigen (HBsAg) double mutants.
Discussion: Compared with rtM204I (sI195M), the YMDD mutation rtM204V ( Discussion: In the current study no changes to the antigenicity of sT118M HBsAg was observed when the drug-resistant mutants rtM204I (sI195M) or rtM204V (sW196S) were present on the sT118M backbone.
[HBV vaccine escape mutations in a chronic hepatitis B patient treated with nucleos(t)ide analogues].
Abstract: However, multiple HBV vaccine-escape mutations (sS143T + sD144E + sG145R + sE164D + sI195M) have been determined on the HBV overlapping pol/S gene region.
Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B.
Result: In patient 1, changes of the P gene, rtW153Q, rtI169L, rtV173L, rtA181V, and rtM204V, corresponded to change of the S gene, rtG145
Discussion: For instance, a change at sI195M, sW196L associated with rtM204V/I was detected in one and two of 100 colonies in patient 1 and 5, respectively.
Combination of allele-specific detection techniques to quantify minority resistance variants in hepatitis B infection: a novel approach.
PMID: 23454647
2013
Journal of virological methods
Introduction: Furthermore, this combination of mutations also alters the overlapping envelope reading frame causing surface antigen (HBsAg) mutations E164D and I195M, which confer a vaccine escape phenotype.
Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome.
Result: The most variable positions were those that overlapped RT residues associated with NA resistance, particularly sI195M, related to rtM204V, present in 5.6% and 99% of sequences at LMV VBK and ETV VBK, respectively.
Abstract: To investigate whether the nucleotide (nucleoside)-induced resistant mutations of HBs potentiate transcription of hfgl2 prothrombinase gene, we generated two mutant HB expression constructs harboring rtM204V/sI195M or rtM204I/sW196L mutations.
Antiviral drug-associated potential vaccine-escape hepatitis B virus mutants in Turkish patients with chronic hepatitis B.
PMID: 21784687
2011
International journal of infectious diseases
Abstract: RESULTS: Seven types of ADAPVEM were detected in the total CHB patients: rtM204V/sI195M, rtM204I/sW196S, rtM204I/sW196L, rtV173L/sE164D, rtA181T/sW172*, rtA181T/
Characterization of hepatitis virus B isolated from a multi-drug refractory patient.
Abstract: Three mutations in the surface (S) antigen region, sC76Y, sP120T and sI195M, were detected in 100%, 100% and 77.3% of the clones, respectively.
High frequency of lamivudine resistance mutations in Brazilian patients co-infected with HIV and hepatitis B.
Abstract: Three patients with the triple polymerase substitution pattern (rtV173L + rtL180M + rtM204V) had associated changes in the envelope gene (sE164D + sI195M).
HBV mutation literature information.
PMID: 
2013
Hepatitis monthly
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