Result: In the pre S/S region, there were sI195M and sQ129H.
Discussion: The resistance mutations rtL180M + rtM204V and rtS202I may be associated to the presence of mutations in the coding region of the HBsAg envelope region (S of the HBV), as found in the patterns I195M, W196L, and G145R, indicating vaccine escape.
Mutations associated with drug resistance and prevalence of vaccine escape mutations in patients with chronic hepatitis B infection.
Abstract: In addition, four mutations in gene S (three cases with the sI195M mutation and one with the W196L mutation), were detected, corresponding to a rate of 6% of vaccine escape mutations.
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Result: However, out of these 20 S-substitutions, 10 (sT114S, sT126I, sP127T, sN131T, sN143S, Discussion: Of these, sI195M and sW196L had been shown to have reduced binding to anti-HBsAg antibodies while a decrease in the antigenicity of the S protein due to the presence of sP127T mutations had been documented.
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Discussion: Sayan reported multiple HBV vaccine-escape mutations (S143T, D144E, G145R, E164D, I195M), of which 3 of them (D144E, S143L and E164D, one case for each) were seen in the current study.
Low prevalence of hepatitis B vaccine escape mutants among individuals born after the initiation of a nationwide vaccination program in Iran.
Abstract: Mutations at sites rt169, rt204, and rt215 resulted in the Y161C, I195M, and C206W mutations at HBsAg.
Amino acid similarities and divergences in the small surface proteins of genotype C hepatitis B viruses between nucleos(t)ide analogue-naive and lamivudine-treated patients with chronic hepatitis B.
Abstract: With little influence on immune escape-associated mutation frequencies within 'a' determinant, LMV-monotherapy significantly induced classical LMVr-associated mirror changes sE164D/rtV173L, sI195M/rtM204V and sW196L/S/rtM204I, as well as non-classical ones sG44E/rtS53N, sT47K/A/rt
Analysis of complete nucleotide sequences of Angolan hepatitis B virus isolates reveals the existence of a separate lineage within genotype E.
Result: The two others, LDA173 and LDA339, displayed the lamivudine resistance triple mutation rtV173L, rtL180M, rtM204V/I which causes the concomitant amino acid substitutions E164D/G and I195M in the small S protein (Table 3).
Occult hepatitis B virus infection among blood donors in Colombia.
Discussion: Lai et al, demonstrated that mutations sL173F, sI195M, and sY200H also related to these mutations rtA181V, rtM204V, and rtV208A, all of them associated to interferon resistance.
Substitution rtq267h of hepatitis B virus increases the weight of replication and Lamivudine resistance.
Result: The results indicated that rtL180M and/or rtM204V/I and/or rtQ267H had no influence on HBsAg and HBeAg expression comparing to that of WT HBV, in spite of the fact that rtM204V and rtM204I led to sI195M and sW196S in S ORF, due to overlapping between S and P gene.
HBV mutation literature information.
PMID: 
2017
Infection and drug resistance
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