literature

HBV mutation literature information.

COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B.

PMID: 32708399 2020 Diagnostics (Basel, Switzerland)

Result: Among these above 94 cases, there were 11 cases carrying additional mt that are not related to drug resistance, such as rtI187V (+ rtV207M) x 2 cases, rtI187V (+ rtS213T), r

Result: In addition, 23 cases had only mt that are not related to drug resistance, such as rtI187V x 20 cases, rtV253I, rtS256C, and rtI187V + rtN248H.

Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis.

PMID: 30202825 2018 Hepatology communications

Table: I187V

Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility.

PMID: 25028473 2014 The Journal of general virology

Abstract: Furthermore, rtI187V HBV remained susceptible towards treatment with LAM or ADV in vitro whereas the combination of the rtI187V substitution with LAM-resistant mutations rendered HBV resistant to LAM but still sensitive to ADV.

Abstract: However, the emergence of the rtI187V substitution significantly impaired viral replication but without affecting drug sensitivity in vitro.

Abstract: In vitro phenotypic assays showed that the viruses bearing the rtI187V substitution had impaired replication efficacy when compared with the WT and the virus carrying rtI187V combined with LAM-resistant single or double mutations showed even

Occult hepatitis B virus infection among blood donors in Colombia.

PMID: 25471066 2014 Virology journal

Result: Additionally, rtR192C, rtI187V and rtT150S substitutions were observed in samples 024, 038 and 123, respectively (Figure 4).

Discussion: Six amino acid substitutions rtL108P, rtR110G

Discussion: This is first report of the mutations rtL108P, rtR110G, rtR192C, rtT150S and rtI187V.

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