Result: No mutations known to cause tenofovir resistance (L180M, A181I/V, A194T, M204V/I, V214A, Q215S, N236T) or lamuvudine (3TC) resistance (L80V/I, I169T, V173L, L180M, A181T, T184S, M204V/I/S, Q215S) were observed.
Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis.
Result: Therefore, rtI169V may have a compensatory role in ETVr HBV as has been described for the rtI169T substitution.( 14 )
Result: Therefore, rtI169V may have a compensatory role in ETVr HBV as has been described for the rtI169T substitution.( 14 ) .
Discussion: Previous findings have suggested that substitutions (e.g., rtI169T) at this amino acid position may act in a compensatory manner in ETVr HBV.( 14 ) Our data suggest that HBV rt169V may also have an adaptive role in ETVr HBV, specifically during the emergence of rtT184L
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Method: Mutation of rtI169T (0.12%), rtT184G (0.06%), rtA194T (0.07%), and rtM250V/L (0.20%) had a very low pooled incidence (Figure 1).
Table: I169T
Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
Method: As previously described, we used the Mutation Reporter Tool (MRT) software (http://hvdr.bioinf.wits.ac.za/mrt/) to look for HBV resistance-associated mutations (RAMs) in the Polymerase catalytic domain represented by major RAMs (A181T/V/S, A194T, M204V/I/S and N236T) and compensatory RAMs (I169T, V173L, L180M, S202G/I and M250V.
Genetic and phylogenic characterization of hepatitis B virus in the eastern part of the Democratic Republic of Congo.
Introduction: According to several clinical practice guidelines and authoritative reviews, NUCr substitutions can be classified into two categories: primary NUCr substitutions at 8 codons (rtI169T, rtA181T/V, rtT184A/C/F/G/I/L/M/S,
Result: However, the relationship between other atypical AA substitutions with susceptibility to NUCs has not been characterized in vitro, such as rtI169L (not typical rtI169T) and rtM204L (not typical rtM204I/V).
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.
3Introduction: The molecular explanation is that ETV resistance usually requires the LAM-resistant ""YMDD mutation(s)"" (rtM204V/I +-L180M) plus an additional ETV 'signature' substitution in the B domain (rtI169T or rtS184G), C domain (rtS202G/I), or E domain (rtM250V)."
Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.
Result: Other substitutions (rtI169T/V, rtP177G, rtT184A/I, rtA194V/T, rtV214A, rtQ215R/H, rtF249A, and rtM250V) were present at low levels (<1%).
Mutational analysis of reverse transcriptase and surface proteins of patients with partial virological response during mono and combination antiviral therapies in genotype D chronic hepatitis B.
Result: Interestingly, residues W153Q, I169T, A200V, and S202G, which are related to LAM resistance, were found only in this group with a frequency between 3.3 and 9.9% (Table 2).
Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study.
HBV mutation literature information.
PMID: 
2019
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