Association between host TNF-alpha, TGF-beta1, p53 polymorphisms, HBV X gene mutation, HBV viral load and the progression of HBV-associated chronic liver disease in Indonesian patients.
Discussion: H94Y and I127L/T/N/S mutations have been associated to K130M/V131I in previous studies.
Discussion: X gene mutations, including R87W/G, I127L/T/N/S and K130M/V131I mutations, were correlated with HBV viral load.
Discussion: There were significant differences in viral load levels between patients with X gene mutations, including R87W/G, I127L/T/N/S and K130M/V131I mutations.
The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
PMID: 30406036
2018
Frontiers in cellular and infection microbiology
Introduction: Mutations within the X gene, including V5M, I127T, K130M, and V131I/L, are risk factors for HCC and may promote the progression of liver degradation (Kim et al.,).
Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients.
Discussion: Several previous studies on HBV genotypes have reported that H94Y, I127T, K130M,
Discussion: The biological mechanisms elucidating the association of V88F, H94Y, I127T, K130M, V131I, and F132Y/I/R mutations with the pathogenesis of HBV infection are unclear.
Discussion: The prevalence of I127T, V131I, and F132Y/I/R mutations showed an increasing trend with increase in severity of disease from the IC to the HCC group.
Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.
Result: Important substitutions in the X gene included I127T, K130M, and V131I whose frequencies in acute infection were 4%, 8% and 12% respectively and in chronic infection were 24.99%, 45.57%, 45.57% respectively.
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Result: immune epitopes of HBx ORF was significantly altered with progression of CHB to HCC, except the changes in BCP region, which induce mutations in overlapping HBx ORF such as T1753C to I127T, A1762T and G1764A to K130M and V131I.
Discussion: 116-127) of HBx are frequently altered in HBV-genotype C and B, but no significant sequence heterogeneity was noted in the epitopes of HBV-genotype D, except three mutations I127T (T1753C), PMID: 23903686
2013
Brazilian journal of medical and biological research
Discussion: In addition, the C1653T, T1753C, A1762T, and G1764A mutations lead to H94Y, I127T, K130M, and V131I amino acid substitutions in HBx.
Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.
Discussion: Regarding the biological aspects, it was suggested that T1753V lead to the enhancement of transactivation and antiproliferation activity of HBx protein by altering HBx aa 127 (I127T/N/S) and enhancement of virus replication leading to persistent infection and higher frequency of HBV-DNA integration events into the human genome.
Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection.
Abstract: All five mutation types (V5M/L, P38S, H94Y, I127T/N, and K130M and V131I) affecting the six codons were found to be related significantly to clinical severity.
Comparison of full length sequences of hepatitis B virus isolates in hepatocellular carcinoma patients and asymptomatic carriers of Korea.
Abstract: Third, mutations (I127T/N, K130M, and V131I) at three codons in the carboxy functional region of X protein were observed in isolates from all three HCC patients.
"Biological impacts of ""hot-spot"" mutations of hepatitis B virus X proteins are genotype B and C differentiated."
PMID: 16094714
2005
World journal of gastroenterology
1Abstract: METHODS: Five types of ""hot-spot"" mutations of genotype B or C HBV X genes, which sequentially lead to the amino acid substitutions of HBx as I127T, F132Y, K130M+V131I, I127T+K130M+V131I, or K130M+V131I+F132Y, respectively, were generated by means of site-directed mutagenesis."
Abstract: As compared to standard genotype C HBx, I127T mutant showed higher transactivation activity, while the other four types of mutants showed no differences.
HBV mutation literature information.
PMID: 
2019
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