Association between host TNF-alpha, TGF-beta1, p53 polymorphisms, HBV X gene mutation, HBV viral load and the progression of HBV-associated chronic liver disease in Indonesian patients.
Abstract: Significant differences in viral load were found in HBV-infected patients who had X gene mutations, such as R87W/G, I127L/T/N/S and K130M/V131I mutations (P<0.05).
Result: There were significant differences in viral load levels in HBV-infected patients who had X gene mutations, as well as the R87W/G, I127L/T/N/S and K130M/V131I mutation (P<0.05).
Discussion: H94Y and I127L/T/N/S mutations have been as
Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.
Discussion: Regarding the biological aspects, it was suggested that T1753V lead to the enhancement of transactivation and antiproliferation activity of HBx protein by altering HBx aa 127 (I127T/N/S) and enhancement of virus replication leading to persistent infection and higher frequency of HBV-DNA integration events into the human genome.
HBV mutation literature information.
PMID: 
2019
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