Result: The point-mutations on the S gene that owned the rates of >30% of the population were: S53L (37.7%), A184V/G (39.3%), and S210K/N/R/S (39.3%); from 15 to <30% were
Table: I126T/N
Discussion: We found mutations as Y100C/F, P120S/T, R122K, I126T/N/S, S132P, M133T/S/L/I, G145R (the vaccine escape mutant, 2%), Y200F/W and Y206H/F/C as same as that were reported from other studies (Hudu et al.
The Impact of HBV Quasispecies Features on Immune Status in HBsAg+/HBsAb+ Patients With HBV Genotype C Using Next-Generation Sequencing.
Abstract: Especially, mutations in antigenic epitopes, such as I126S in CHB and I126T in HCC, could impact the conformational structure and alter the antigenicity/immunogenicity of HBsAg.
"Characteristics of amino acid substitutions within the ""a"" determinant region of hepatitis B virus in chronically infected patients with coexisting HBsAg and anti-HBs."
PMID: 31624004
2020
Clinics and research in hepatology and gastroenterology
Abstract: The most frequent amino acid substitution was located at position s126 and the predominant substitution was sI126T in HBsAg+/anti-HBs+ patients with genotype C.
The modulation of HBsAg level by sI126T is affected by additional amino acid substitutions in the S region of HBV.
PMID: 31442597
2019
Infection, genetics and evolution
Abstract: Among different substitution types at sI126, the sI126T (N = 28) was found to be associated with significantly lower serum HBsAg level.
Abstract: Clone sequencing revealed that sI126T-harboring SHBs sequences had varied genetic backbones with zero to nine additional AA substitutions.
Abstract: Our findings suggest that the modulation of HBsAg level by sI126T is affected by additional AA substitution(s) in the S region of HBV.
Abstract: Thus, we constructed 24 HBsAg expression plasmids harboring s
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Result: I126S/T, known as an escape mutation in the alpha determinant region, was found only in HBsAg-positive HCC (Table 3).
Result: Differences in the major populations were attributed to the I126S/T, Y200F/S, and Y206C/H/S mutations, while those in the minor populations were attributed to the
Table: I126S/T
Discussion: In present study, I126S/T mutants were detected only in HBsAg-positive cases, and it was suggested that the titre of HBsAg of these cases might decrease over a long-term follow-up period.
Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.
Discussion: In contrast, the frequencies of L110I, T113S and I126T, which may be compensatory mutations, increased in the S region.
Discussion: In the present study, data from ultra-deep sequencing revealed that mutants harboring different mutations, including G145R and I126T, coexisted in the patient.
Discussion: The presence of amino-acid substitutions in the MHR of HBsAg, such as G145R and I126T, can change the immunogenicity of HBsAg, thus resulting in HBsAg/anti-HBs coexistence and immune escape.
Molecular evolution of hepatitis B vaccine escape variants in China, during 2000-2016.
Abstract: Four sites (A5T/S, L21S, T/A126S and T/N131I/A) and 13 sites (N3S, T5A, G10Q/R/E, L21S, T47K/A/V, L98V/P, I/S126N/V/T, Q129H/R/L, T131P/I/N/A, G145A/R, L175S/F, L213I/S, V224A/G) were found to be under positive selection in genotype B and C HBV vaccine escape strains, re
Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.
Result: Only I126T was found in five subjects of the control group (C4, C8, C15, C16, and C20), although this mutation was not found in the occult HBV infection group.
Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
Result: To note, 75.00% (9/12) of their sequences harbor one or two of our newly identified SHBs mutations (sL21R, sT47K, sL95W, sK122R, sI126T, sG145R and sW182*) (Supplementary Table 2).
Discussion: Moreover, we discovered that HBV mutants sS117T, sK122R, sI126
HBV mutation literature information.
PMID: 
2022
PloS one
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