Result: The point-mutations on the S gene that owned the rates of >30% of the population were: S53L (37.7%), A184V/G (39.3%), and S210K/N/R/S (39.3%); from 15 to <30% were L21S (29.1%),
Discussion: We found mutations as Y100C/F, P120S/T, R122K, I126T/N/S, S132P, M133T/S/L/I, G145R (the vaccine escape mutant, 2%), Y200F/W and Y206H/F/C as same as that were reported from other studies (Hudu et al.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Introduction: Across different genotypes, the most frequent substitutions were I/T126S (1.8%), G145R (1.2%), M133T (1.2%), Q129R (1.0%), I/T126A (0.8%), and P120T (0.8%).
The Impact of HBV Quasispecies Features on Immune Status in HBsAg+/HBsAb+ Patients With HBV Genotype C Using Next-Generation Sequencing.
Abstract: Especially, mutations in antigenic epitopes, such as I126S in CHB and I126T in HCC, could impact the conformational structure and alter the antigenicity/immunogenicity of HBsAg.
Characterization of Antigen Escape Mutations in Chronic HBV-Infected Patients in Upper Egypt.
8Discussion: Several other studies reported other substitutions in the ""a"" determinant region and associated with vaccine escape, such as T116N, P120S/E, I/T126A/N/I/S, Q129H/R, M133L, K141E, and D144A/E."
Detection of Q129H Immune Escape Mutation in Apparently Healthy Hepatitis B Virus Carriers in Southwestern Nigeria.
Introduction: In the following years, other mutations observed on the a-determinant, which are considered as immune escape variants, including T116N, P120S/E, I/T126A/N/I/S, Q129H/R, M133L, K141E, P142S, and D144A/E, have also been reported.
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region.
Result: These major mutations were more frequent in genotypes A (P120T, 3.2%), B (I/T126A, 2.8%; Q129R, 2.2%), C (I/T126S, 3.9%; M133T, 1.9%), and G (G145R, 5.0%).
Discussion: Only 4 of the 25 escape mutations had total frequencies of >=1% (I/T126S, 1.8%; G145R, 1.2%; M133T, 1.2%; and Q129R, 1.0%), consistent with a previous large-scale analysis showing frequencies of no less than 1% for most escape mutations.
Discussion: Particularly, the most common escape mutation identified, I/T126S, was previously associated with vaccine failure in Chinese adults undergoing the HBV vacc
Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.
PMID: 32994690
2020
World journal of gastroenterology
Result: In particular, mutations were detected in 67/63/168 of 298 sQ101H/K/R-positive patients, 39/2/76 of 117 sS114A/L/T-positive patients, 5/5/15/3/1/2 of 31 sT118A/K/M/R/S/V-positive patients, 3/0/0/23/81 of 107 sP120A/L/Q/S/T-positive patients, 94/58/0/214 of 366 sT/I126A/N/P/S-positive patients, 14/46/136 of 196 sM133I/L/T-positive patients, 1/8 of 9 sC137W/Y-positive patient
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Result: Discussion: Although previous studies have already confirmed that the mutations in MHR, especially in the 'a' determinant influenced the virus antigenicity and were significantly associated with vaccine escape, we observed that the vaccine escaped mutations occurred frequently in the 'a' determinant (T116 N (4.3%), P120S (4.3%), T126A (8.7%), Q129R/H (17.3%), D144A/E (8.7%) and G145A/R (21.7%) for OBIB and T116 N (4.3%), I126S (8.7%), Q129R (8.7%), D144E (4.3%) and G145A/R (17.4%) for OBIC).
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
4Method: Of these, a RT mutation in the A-B interdomain, rtD134E/N, which also cause a simultaneous sI126N/S mutation of the HBsAg ""a"" determinant, was found to have the highest frequency in treatment-naive patients (1.70%) (Figure 2)."
Method: Notably, these authors also found that RT mutations in the A-B interdomain could lead to simultaneous AA substitutions sI126A/N/S/, sG130N, sT131N/P, and sG145R of the overlapped '
Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.
Result: I126S/T, known as an escape mutation in the alpha determinant region, was found only in HBsAg-positive HCC (Table 3).
Result: Differences in the major populations were attributed to the I126S/T, Y200F/S, and Y206C/H/S mutations, while those in the minor populations were attributed to the L21F/S, L42F/S, W182Stop, and L213F/I/T mutations.
Table: I126S/T
Discussion: In present study, I126S/T mutants were detected only in
ViMRT
HBV mutation literature information.
PMID: 
2022
PloS one
