literature

HBV mutation literature information.

Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.

PMID: 28332361 2017 Yonsei medical journal

Discussion: The 'a' determinant mutations found in this study were I126M/N, P127S/T, T131N, S132F, M133T, F134L/T, D144E, and G145A.

Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.

PMID: 27650283 2017 Journal of hepatology

Result: revealed previously identified immune escape mutations within the 'a' determinant region (sS117T, sK122R, sI126N/S/T, and sG145R), carboxyl terminal truncation mutations (sC69* and sW182*) and additional rarely described mutations (sE2G, sL21S, sR24K, sT47K/A

HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.

PMID: 27167598 2017 Antiviral therapy

Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (

Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China.

PMID: 23951004 2013 PloS one

Discussion: Other common escape mutations, including G145R, D144A, P142S, Q129H, I/T126N/A and M133L, were not found in our OBI isolates.

Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.

PMID: 22882650 2012 Liver international

Discussion: And rtD134E/G/N/S mutation could also generate the sI126N/V mutation in the S gene of HBV.

A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.

PMID: 22720022 2012 PloS one

Result: Mutations associated with immune escape were identified in 23.5% (n = 45/187) samples and included the following residues Y100C (n = 6), T118K (n = 1), P120L/Q/S/T (n = 10), T123A/N (n = 2), I126N/S (n = 8), P127S (n = 2), Q129R (n = 2), G130D/N/R (n = 1), T131I (n = 4), M133L/T (n = 18), G144E (n = 1) and G145A/R (n = 4).

Diversity of hepatitis B virus infecting Malaysian candidate blood donors is driven by viral and host factors.

PMID: 20196797 2011 Journal of viral hepatitis

Abstract: HBV vaccine escape substitutions (P120S/T, I126N and G145G) were present in six strains.

Molecular epidemiological study of hepatitis B virus among migrant workers from Cambodia, Laos, and Myanmar to Thailand.

PMID: 20572086 2010 Journal of medical virology

1Abstract: Various point mutations in the ""a"" determinant region were detected in approximately 18% of these samples, of which Ile126Ser/Asn was the most frequent variant."

Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients.

PMID: 19301976 2009 The Journal of infectious diseases

Method: Mutations at 10 S envelope protein positions were considered possible vaccine-escape mutations, including sP120T, sI/T126N/A, sQ129H, sM133L, sK141E, sP142S, sD144A, sG145R, sF158Y, and s

PMID: 11851835 2001 Journal of gastroenterology and hepatology

Abstract: Four out of these six cases had a point mutation within the 'a' determinant; they were Gly-145-Ala, and Ile/Thr-126-Asn/Ser.

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