literature

Molecular characterization of hepatitis B virus in Vietnam.

PMID: 28859616 2017 BMC infectious diseases

4Method: The S gene sequence was analyzed for mutations in the ""a"" determinant region (T116 N, P120S/T, I/T126S/A, Q129H/R, M133 L/T, K141E, P142S, D144E, and G145R), and other virulence associated mutations (N3S, V184A, and S204R)."

5Result: Among the isolates, 8.1% (11/135) had a mutation in the ""a"" determinant region including 2.2% (3/135) P120S/T, 2.2% (3/135) I/T126S/A, 3% (4/135)

PMID: 26136564 2015 Journal of virology

Abstract: A small domain (matrix domain [MD]) in the large surface protein L and a narrow region (matrix binding domain [MBD]) including isoleucine 126 on the capsid surface have been mapped, in which point mutations such as core I126A specifically blocked nucleocapsid envelopment.

Abstract: By the systematic evolution of ligands by exponential enrichment (SELEX) method, we evolved DNA aptamers from an oligonucleotide library binding to purified recombinant capsids but not binding to the corresponding I126A mutant capsids.

Abstract: Its Kd for I126A capsids was 1,306 +- 503 nM.

Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China.

PMID: 23951004 2013 PloS one

Discussion: Other common escape mutations, including G145R, D144A, P142S, Q129H, I/T126N/A and M133L, were not found in our OBI isolates.

Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients.

PMID: 19301976 2009 The Journal of infectious diseases

Method: Mutations at 10 S envelope protein positions were considered possible vaccine-escape mutations, including sP120T, sI/T126N/A, sQ129H, sM133L, sK141E, sP142S, sD144A, sG145R, sF158Y, and s

PMID: 18431229 2008 Transplantation

Abstract: Three of the lamivudine and HBIg cohort had the I126A Hepatitis B surface antigen escape variant.