Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Method: Of the two sites in RT related to HCC outcomes, rtD134N (mutation G529A) was associated with lamivudine resistance, further supporting previous findings of potential correlation between resistance to the anti-HBV nucleoside analog, lamivudine, and HCC prognosis.
Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.
Discussion: G529A and T1078G were located in the RT domain of polymerase, which possesses RT and DNA-dependent DNA polymerase activity.
Discussion: Further functional research is required to determine whether the amino acid residue changes induced by G529A and T1078G would result in altered RT activity so as to modify HBV replication and cell proliferation in HCC.
Discussion: The G529A mutation did not result in a structural change in HBsAg, which could induce changes in the antigenic properties of HBV.
Discussion: The lamivudine res
Nucleotide mutations associated with hepatitis B e antigen negativity.
Abstract: Six mutations were found to be significantly more common in the former group than in the latter: G529A (3/4 vs. 0/5), C934A (4/4 vs. 1/5), A1053G (4/4 vs. 1/5), G1915T/A (4/4 vs. 0/5), T2005C/A (4/4 vs. 0/5), and C3026T (3/4 vs. 0/5).
HBV mutation literature information.
PMID: 
2018
World journal of gastroenterology
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